Vector priming reduces the immunogenicity of Salmonella-based vaccines in Nramp1+/+ mice

被引：9

作者：

Vindurampulle, CJ ^{[1
]}

Attridge, SR ^{[1
]}

机构：

[1] Univ Adelaide, Dept Mol Biosci, Adelaide, SA 5005, Australia

来源：

INFECTION AND IMMUNITY | 2003年 / 71卷 / 04期

关键词：

D O I：

10.1128/IAI.71.4.2258-2261.2003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The present studies in Nramp1(-/-) BALB/c and Nramp1(+/+) CBA mice question the significance of this genotype as a determinant of the level of gut colonization following oral administration of naturally attenuated or highly virulent Salmonella strains. In line with previous results in BALB/c hosts, vector priming of CBA mice with Salmonella enterica serovar Stanley was found to significantly compromise the immunogenicity of a recombinant construct expressing a foreign pilus protein.

引用

页码：2258 / 2261

页数：4

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