Stability of the OECD model compound benzoic acid in receptor fluids of Franz diffusion cells

被引：6

作者：

Bode, S.

Baert, B.

Vangele, M.

Lambert, J.

Burvenich, C.

Slegers, G.

De Spiegeleer, B.

机构：

[1] Univ Ghent, Fac Pharmaceut Sci, Dept Pharmaceut Anal, DruQuaR Grp, B-9000 Ghent, Belgium

[2] Univ Ghent, Fac Med & Hlth Sci, Dept Dermatol, B-9000 Ghent, Belgium

[3] Univ Ghent, Fac Vet Med, Dept Physiol & Biometry, B-9000 Ghent, Belgium

来源：

PHARMAZIE | 2007年 / 62卷 / 06期

关键词：

D O I：

10.1691/ph.2007.6.6307

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The stability of benzoic acid, one of the model compounds recommended for skin absorption studies in the OECD guidelines, in Franz diffusion cell receptor fluids was studied. According to the results, addition of a preservative (sodium azide) to the solution is recommended for long-term skin permeation experiments.

引用

页码：470 / 471

页数：2

共 5 条

[1] Enhancement of transdermal absorption by switching iontophoresis [J].

Ishikawa, O ;

Kato, Y ;

Onishi, H ;

Nagai, T ;

Machida, Y .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2002, 249 (1-2) :81-88

[2]

Kitagawa S, 2000, CHEM PHARM BULL, V48, P1698

[3] Natural oils affect the human skin integrity and the percutaneous penetration of benzoic acid dose-dependently [J].

Nielsen, Jesper B. .

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2006, 98 (06) :575-581

[4] In vitro predictions of skin absorption of caffeine, testosterone, and benzoic acid: a multi-centre comparison study [J].

van de Sandt, JJM ;

van Burgsteden, JA ;

Cage, S ;

Carmichael, PL ;

Dick, I ;

Kenyon, S ;

Korinth, G ;

Larese, F ;

Limasset, JC ;

Maas, WJM ;

Montomoli, L ;

Nielsen, JB ;

Payan, JP ;

Robinson, E ;

Sartorelli, P ;

Schaller, KH ;

Wilkinson, SC ;

Williams, FM .

REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2004, 39 (03) :271-281

[5]

Yoshida M, 2000, CHEM PHARM BULL, V48, P1807

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