Controversies in rheumatology: maintenance therapy with low-dose glucocorticoids in rheumatoid arthritis

被引：4

作者：

Buttgereit, Frank ^{[1
]}

Kvien, Tore K. ^{[2
]}

机构：

[1] Charite, Dept Rheumatol & Clin Immunol, Charitepl 1, D-10117 Berlin, Germany

[2] Diakonhjemmet Hosp, Div Rheumatol & Res, Oslo, Norway

来源：

RHEUMATOLOGY | 2022年 / 62卷 / 01期

关键词：

RA; prednisone; low-dose glucocorticoids; benefit-risk ratio; REMISSION; STRATEGY;

D O I：

10.1093/rheumatology/keac355

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Since the beginning of the use of glucocorticoids in clinical medicine, the risk-benefit ratio of these still very important drugs has been debated. There is no doubt that they produce many desirable therapeutic effects quickly and reliably. However, their potential to cause adverse effects, especially with prolonged use in high doses, limits their applicability. We discuss the arguments against and in favour of maintenance therapy with low-dose glucocorticoids in patients with RA, and present recent studies, assessments and conclusions on this question.

引用

页码：35 / 41

页数：7

共 32 条

[11] A two-step treatment strategy trial in patients with early arthritis aimed at achieving remission: the IMPROVED study [J].

Heimans, L. ;

Wevers-de Boer, K. V. C. ;

Visser, K. ;

Goekoop, R. J. ;

van Oosterhout, M. ;

Harbers, J. B. ;

Bijkerk, C. ;

Speyer, I. ;

de Buck, M. P. D. M. ;

de Sonnaville, P. B. J. ;

Grillet, B. A. M. ;

Huizinga, T. W. J. ;

Allaart, C. F. .

ANNALS OF THE RHEUMATIC DISEASES, 2014, 73 (07) :1356-1361

[12] Short- and long-term efficacy of intra-articular injections with betamethasone as part of a treat-to-target strategy in early rheumatoid arthritis: impact of joint area, repeated injections, MRI findings, anti-CCP, IgM-RF and CRP [J].

Hetland, Merete Lund ;

Ostergaard, Mikkel ;

Ejbjerg, Bo ;

Jacobsen, Soren ;

Stengaard-Pedersen, Kristian ;

Junker, Peter ;

Lottenburger, Tine ;

Hansen, Ib ;

Andersen, Lis Smedegaard ;

Tarp, Ulrik ;

Svendsen, Anders ;

Pedersen, Jens Kristian ;

Skjodt, Henrik ;

Ellingsen, Torkell ;

Lindegaard, Hanne ;

Podenphant, Jan ;

Horslev-Petersen, Kim .

ANNALS OF THE RHEUMATIC DISEASES, 2012, 71 (06) :851-856

[13] Shift From Adalimumab Originator to Biosimilars in Denmark [J].

Jensen, Thomas Bo ;

Kim, Seoyoung C. ;

Jimenez-Solem, Espen ;

Bartels, Dorthe ;

Christensen, Hanne Rolighed ;

Andersen, Jon Traerup .

JAMA INTERNAL MEDICINE, 2020, 180 (06) :902-903

[14] Effects of glucocorticoids on radiological progression in rheumatoid arthritis [J].

Kirwan, J. R. ;

Bijlsma, J. W. J. ;

Boers, M. ;

Shea, B. J. .

COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2007, (01)

[15] THE EFFECT OF GLUCOCORTICOIDS ON JOINT DESTRUCTION IN RHEUMATOID-ARTHRITIS [J].

KIRWAN, JR ;

BYRON, M ;

DIEPPE, P ;

EASTMOND, C ;

HALSEY, J ;

HICKLING, P ;

HOLLINGWORTH, P ;

JACOBY, R ;

KIRK, A ;

MORAN, C ;

REID, D ;

SWANNELL, T ;

YATES, D ;

COOPER, C ;

GEORGE, E ;

FORBES, D ;

JESSOP, J ;

WATT, I .

NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (03) :142-146

[16] Confounding by Indication in Clinical Research [J].

Kyriacou, Demetrios N. ;

Lewis, Roger J. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2016, 316 (17) :1818-1819

[17] Mortality in rheumatoid arthritis: the impact of disease activity, treatment with glucocorticoids, TNFα inhibitors and rituximab [J].

Listing, Joachim ;

Kekow, Joern ;

Manger, Bernhard ;

Burmester, Gerd-Ruediger ;

Pattloch, Dagmar ;

Zink, Angela ;

Strangfeld, Anja .

ANNALS OF THE RHEUMATIC DISEASES, 2015, 74 (02) :415-421

[18]

Mulhearn B, 2023, ANN RHEUM DIS, V82, DOI 10.1136/annrheumdis-2021-220099

[19] Two-year cost-effectiveness of different COBRA-like intensive remission induction schemes in early rheumatoid arthritis: a piggyback study on the pragmatic randomised controlled CareRA trial [J].

Pazmino, Sofia ;

Boonen, Annelies ;

Stouten, Veerle ;

De Cock, Diederik ;

Joly, Johan ;

Van der Elst, Kristien ;

Westhovens, Rene ;

Verschueren, Patrick .

ANNALS OF THE RHEUMATIC DISEASES, 2020, 79 (05) :556-565

[20] Inequities in access to biologic and synthetic DMARDs across 46 European countries [J].

Putrik, Polina ;

Ramiro, Sofia ;

Kvien, Tore K. ;

Sokka, Tuulikki ;

Pavlova, Milena ;

Uhlig, Till ;

Boonen, Annelies .

ANNALS OF THE RHEUMATIC DISEASES, 2014, 73 (01) :198-206

← 1 2 3 4 →