The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42

被引：742

作者：

Joberty, G ^{[1
]}

Petersen, C ^{[1
]}

Gao, L ^{[1
]}

Macara, IG ^{[1
]}

机构：

[1] Univ Virginia, Hlth Sci Ctr, Markey Ctr Cell Signaling, Charlottesville, VA 22908 USA

来源：

NATURE CELL BIOLOGY | 2000年 / 2卷 / 08期

关键词：

D O I：

10.1038/35019573

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

PAR (partitioning-defective) proteins, wh ich were first identified in the nematode Caenorhabditis elegans, are essential for asymmetric cell division and polarized growth, whereas Cdc42 mediates establishment of cell polarity. Here we describe an unexpected link between these two systems. We have identified a family of mammalian Pare proteins that are similar to the C. elegans PDZ-domain protein PAR-6. Par6 forms a complex with Cdc42-GTP, with a human homologue of the multi-PDZ protein PAR-3 and with the regulatory domains of atypical protein kinase C (PKC) proteins. This assembly is implicated in the formation of normal tight junctions at epithelial cell-cell contacts. Thus, Pare is a key adaptor that links Cdc42 and atypical PKCs to Par3.

引用

页码：531 / 539

页数：9

共 38 条

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