Circulating miRNAs in blood and urine as diagnostic and prognostic biomarkers for bladder cancer: an update in 2017

被引：22

作者：

Toelle, Angelika ^{[1
,2
]}

Blobel, Conrad C. ^{[1
]}

Jung, Klaus ^{[3
]}

机构：

[1] Charite Univ Med Berlin, Dept Urol, D-10117 Berlin, Germany

[2] CONGEN Biotechnol GmbH, D-13125 Berlin, Germany

[3] Berlin Inst Urol Res, D-10117 Berlin, Germany

来源：

BIOMARKERS IN MEDICINE | 2018年 / 12卷 / 06期

关键词：

biomarker; bladder cancer; diagnosis; miRNA; plasma; prognosis factor; RT-PCR; reference gene urine; serum; MICRORNA EXPRESSION SIGNATURES; NONINVASIVE BIOMARKERS; UROTHELIAL CARCINOMA; PLASMA MICRORNA; REFERENCE GENES; SERUM; IDENTIFICATION; RECURRENCE; GUIDELINES; PREDICTION;

D O I：

10.2217/bmm-2017-0392

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

This study presents a critical appraisal of previously published study data of miRNAs in blood, urine and exosomes as biomarkers of bladder cancer (BC). The evaluation included 39 articles published from the beginning of 2010 until September 2017 and searched in PubMed. The heterogeneity of studies, due to their clinicopathological variability, including insufficient consideration of diagnostic and prognostic biomarker guidelines and missing internal and external validation of data, do not currently allow the recommending of a useful miRNA marker as diagnostic or prognostic tool in BC. Future multi-institutional studies are necessary to overcome the deficiencies in these studies in order to prove the usefulness of circulating miRNAs as robust biomarkers for BC.

引用

页码：667 / 676

页数：10

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