Anti-inflammatory and antipyretic effects of Sonchus oleraceus in rats

被引：41

作者：

Vilela, Fabiana C. ^{[1
]}

Bitencourt, Andressa D. ^{[1
]}

Cabral, Layla D. M. ^{[1
]}

Franqui, Lidiane S. ^{[1
]}

Soncini, Roseli ^{[1
]}

Giusti-Paiva, Alexandre ^{[1
]}

机构：

[1] Univ Fed Alfenas MG, Dept Ciencias Biomed, BR-37130000 Alfenas, MG, Brazil

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2010年 / 127卷 / 03期

关键词：

Asteraceae; Edema; Fever; Inflammation; Peritonitis; SEPTIC SHOCK; NITRIC-OXIDE; VASOPRESSIN; BRAZIL; EDEMA; ASPER; DIET; MICE; PAW; L;

D O I：

10.1016/j.jep.2009.11.030

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Ethnopharmacological relevance: Sonchus oleraceus L. has been used to relieve headaches, general pain, hepatitis, infections, inflammation and rheumatism in Brazilian folk medicine. Nevertheless, scientific information regarding this species is scarce; there are no reports related to its possible anti-inflammatory effects. Aim of the study: This study was aimed at evaluating the scientific basis for the traditional use of Sonchus oleraceus using in vivo inflammatory models. Materials and methods: Carrageenan-induced paw edema, peritonitis and febrile response induced by lipopolysaccharide tests, as well as fibrovascular tissue growth induced by s.c. cotton pellet implantation were used to investigate the anti-inflammatory activity of Sonchus oleraceus hydroethanolic extract (SoHE) in rats. Results: The SoHE at test doses of 100-300 mg/kg p.o. clearly demonstrated anti-inflammatory effects by reduced paw edema induced by carragenan, inhibited leukocyte recruitment into the peritoneal cavity and reduced LPS-induced febrile response, and in the model of chronic inflammation using the cotton pellet-induced fibrovascular tissue growth in rats, the SoHE significantly inhibited the formation of granulomatous tissue. The extract administered at 300 mg/kg p.o. had a stronger anti-inflammatory effect than indomethacin (10 mg/kg) or dexamethasone (1 mg/kg). Conclusion: The hydroethanolic extract of Sonchus oleraceus markedly demonstrated anti-inflammatory action in rats, which supports previous claims of its traditional use. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：737 / 741

页数：5

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