Diabetes and Glucose Metabolism in Thalassemia Major: An Update

被引：44

作者：

De Sanctis, Vincenzo ^{[1
]}

Soliman, Ashraf T. ^{[2
]}

Elsedfy, Heba ^{[3
]}

Pepe, Alessia ^{[4
,5
]}

Kattamis, Christos ^{[6
]}

El Kholy, Mohamed ^{[3
]}

Yassin, Mohamed ^{[7
]}

机构：

[1] Quisisana Hosp, Pediat & Adolescent Outpatient Clin, I-44100 Ferrara, Italy

[2] Univ Alexandria, Childrens Hosp, Dept Pediat, Div Endocrinol, Alexandria, Egypt

[3] Ain Shams Univ, Dept Pediat, Cairo, Egypt

[4] Fdn G Monasterio CNR Reg Toscana, Cardiovasc MR Unit, Pisa, Italy

[5] CNR, Inst Clin Physiol, Via Savi 8, I-56100 Pisa, Italy

[6] Univ Athens, Dept Pediat 1, Athens, Greece

[7] Hamad Med Corp, Dept Hematol & BMT, Natl Ctr Canc Care & Res, Doha, Qatar

来源：

EXPERT REVIEW OF HEMATOLOGY | 2016年 / 9卷 / 04期

关键词：

Continuous glucose monitoring system; Glucose homeostasis; Thalassemia; Treatment; Magnetic resonance imaging; Iron overload; SICKLE-CELL-DISEASE; BETA-THALASSEMIA; IRON OVERLOAD; MAGNETIC-RESONANCE; ENDOCRINE COMPLICATIONS; INSULIN-SECRETION; PANCREATIC IRON; TOLERANCE; MELLITUS;

D O I：

10.1586/17474086.2016.1136209

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In patients with TM, uncontrolled iron overload has serious clinical consequences with considerable morbidity and mortality. Complications include liver damage, cardiac disease and endocrine dysfunction. Diabetes is an important complication of TM. The mechanisms of abnormal glucose homeostasis are complex and multifactorial. This review updates the current knowledge about glycemic abnormalities in TM patients and directs the attention to an early diagnosis and proper management

引用

页码：401 / 408

页数：8

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