EML4-ALK positive lung adenocarcinoma with skeletal muscle metastasis in the right calf which was treatable with lorlatinib after resistance to treatment with alectinib

被引:1
作者
Matsuda, Hironari [1 ]
Hara, Munechika [1 ]
Iwakami, Shin-Ichiro [1 ]
Takahashi, Kazuhisa [2 ]
机构
[1] Juntendo Shizuoka Hosp, Dept Resp Med, Izunokuni, Shizuoka, Japan
[2] Juntendo Univ, Dept Resp Med, Sch Med, Grad Sch Med,Bunkyo Ku, Tokyo, Japan
关键词
lung cancer (oncology); cancer intervention; malignant disease and immunosuppression; CANCER; CHEMOTHERAPY; CARCINOMA;
D O I
10.1136/bcr-2020-240295
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
This report concerns a patient with skeletal muscle metastases due to lung adenocarcinoma harbouring an echinoderm microtubule-associated protein-like-4 (EML4)-anaplastic lymphoma kinase (ALK) rearrangement, who was successfully treated with lorlatinib after resistance to alectinib. A right lower lobectomy based on a diagnosis of lung adenocarcinoma was performed on a 77-year-old Japanese woman. After 7 months of surgical resection, a mass in the right calf was observed. A fine-needle aspiration biopsy from the mass was performed and the mass was diagnosed as metastatic adenocarcinoma harbouring EML4-ALK rearrangement. Alectinib was administered for 10 months. Then, administration of lorlatinib, an ALK tyrosine kinase inhibitor classified as third generation, was initiated after resistance to treatment with alectinib. After starting treatment with lorlatinib, the gastrocnemius tumour diminished and has maintained a stable condition. Our case suggests that EML4-ALK positive lung adenocarcinoma is treatable with lorlatinib after resistance to treatment with alectinib.
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页数:4
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