Opioid tolerance and hyperalgesia

被引：137

作者：

Chang, Grace ^{[1
]}

Chen, Lucy ^{[1
]}

Mao, Jianren ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Pain Ctr,Div Pain Med,Dept Anesthesia & Crit Care, Boston, MA 02114 USA

来源：

MEDICAL CLINICS OF NORTH AMERICA | 2007年 / 91卷 / 02期

关键词：

D O I：

10.1016/j.mcna.2006.10.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Opioids have been successfully used for the management of acute and cancer-related pain. Concerns regarding side effects, tolerance, dependence, addiction, and hyperalgesia have limited the use of opioids for the management of chronic nonmalignant pain. This article will review updated information from both clinical and preclinical studies regarding opioid-induced hyperalgesia, tolerance, and dependence. The implications of these issues in clinical opioid therapy also will be discussed.

引用

页码：199 / +

页数：14

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