Overlap of IgG4-related Disease and Multicentric Castleman's Disease in a Patient with Skin Lesions

被引：14

作者：

Mochizuki, Hiroki ^{[1
]}

Kato, Manako ^{[1
]}

Higuchi, Takakazu ^{[2
]}

Koyamada, Ryosuke ^{[2
]}

Arai, Satoru ^{[3
]}

Okada, Sadamu ^{[2
]}

Eto, Hikaru ^{[3
]}

机构：

[1] St Lukes Int Hosp, Internal Med, Tokyo, Japan

[2] St Lukes Int Hosp, Div Hematol, Tokyo, Japan

[3] St Lukes Int Hosp, Dept Dermatol, Tokyo, Japan

来源：

INTERNAL MEDICINE | 2017年 / 56卷 / 09期

关键词：

IgG4-related disease; multicentric Castleman's disease; skin lesion; rituximab; LUNG-DISEASE; CT FINDINGS; MANIFESTATIONS; STATEMENT; RITUXIMAB;

D O I：

10.2169/internalmedicine.56.8013

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 59-year-old man presented with multiple dark red erythemas with induration, anemia, and polyclonal hypergammaglobulinemia. A skin biopsy revealed the infiltration of lymphocytes and plasma cells and he was initially diagnosed with multicentric Castleman's disease (MCD). Glucocorticoid treatment was only partially effective. Four years later, the patient's bilateral lacrimal glands gradually became enlarged and a biopsy revealed dense lymphocyte and plasma cell infiltration with an IgG4+/IgG+ plasma cell ratio of 70%. The patient was diagnosed with IgG4-related disease (RD). Rituximab only had a slight effect. This case demonstrates that overlapping features of IgG4-RD and MCD may present in a single patient, which suggests a shared pathogenesis.

引用

页码：1095 / 1099

页数：5

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