Failure to find an association between myosin heavy chain 9, non-muscle (MYH9) and schizophrenia: A three-stage case-control association study

被引：5

作者：

Amagane, Hideki ^{[1
]}

Watanabe, Yuichiro ^{[1
,2
]}

Kaneko, Naoshi ^{[1
]}

Nunokawa, Ayako ^{[1
]}

Muratake, Tatsuyuki ^{[3
]}

Ishiguro, Hiroki ^{[4
]}

Arinami, Tadao ^{[4
]}

Ujike, Hiroshi ^{[5
]}

Inada, Toshiya ^{[6
]}

Iwata, Nakao ^{[7
]}

Kunugi, Hiroshi ^{[8
]}

Sasaki, Tsukasa ^{[9
]}

Hashimoto, Ryota ^{[10
]}

Itokawa, Masanari ^{[11
]}

Ozaki, Norio ^{[12
]}

Someya, Toshiyuki ^{[1
]}

机构：

[1] Niigata Univ, Dept Psychiat, Grad Sch Med & Dent Sci, Chuo Ku, Niigata 9518510, Japan

[2] Niigata Univ, Hlth Adm Ctr, Nishi Ku, Niigata 9502181, Japan

[3] Furumachi Mental Clin, Chuo Ku, Niigata 9518063, Japan

[4] Univ Tsukuba, Dept Med Genet, Doctoral Program Social & Environm Med, Grad Sch Comprehens Human Sci, Tsukuba, Ibaraki 3058575, Japan

[5] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neuropsychiat, Okayama 7008558, Japan

[6] Seiwa Hosp, Inst Neuropsychiat, Shinjuku Ku, Tokyo 1620851, Japan

[7] Fujita Hlth Univ, Sch Med, Dept Psychiat, Aichi 4701192, Japan

[8] Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Mental Disorder Res, Kodaira, Tokyo 1878502, Japan

[9] Univ Tokyo, Hlth Serv Ctr, Bunkyo Ku, Tokyo 1138655, Japan

[10] Osaka Univ, Grad Sch Med, Osaka Hamamatsu Joint Res Ctr Child Mental Dev, Suita, Osaka 5650871, Japan

[11] Tokyo Inst Psychiat, Schizophrenia Res Project, Setagaya Ku, Tokyo 1568585, Japan

[12] Nagoya Univ, Dept Psychiat, Sch Med, Showa Ku, Aichi 4668550, Japan

来源：

SCHIZOPHRENIA RESEARCH | 2010年 / 118卷 / 1-3期

关键词：

Chromosome; 22; Case-control study; Japanese; MYH9; Schizophrenia; GENOME-WIDE ASSOCIATION; 22Q11 DELETION SYNDROME; SUSCEPTIBILITY LOCI; BIPOLAR DISORDER; COMMON VARIANTS; LINKAGE; GENE; METAANALYSIS; IDENTIFICATION; CANDIDATE;

D O I：

10.1016/j.schres.2010.01.023

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Several genome-wide linkage studies have suggested linkage between markers on the long arm of chromosome 22 and schizophrenia. It has also been reported that 22q11.2 deletions increase the risk of schizophrenia. Therefore, 22q is a candidate region for schizophrenia. To search for genetic susceptibility loci for schizophrenia on 22q, we conducted a three-stage case-control association study in Japanese individuals. In the first stage, we examined 13 microsatellite markers on 22q in 766 individuals (340 patients with schizophrenia and 426 control individuals) and found a potential association of AFM262VH5 (D22S283) with schizophrenia. In the second stage, we performed fine mapping of the myosin heavy chain 9, non-muscle (MYH9) gene, where AFM262VH5 is located, using 25 tagging single nucleotide polymorphisms (SNPs). We obtained potential associations between three SNPs in MYH9 and schizophrenia in 1193 individuals (595 patients and 598 controls), which included the individuals analyzed in the first stage. In the third stage, however, we could not replicate these associations in 4694 independent individuals (2288 patients and 2406 controls). Our results suggest that MYH9 does not confer increased susceptibility to schizophrenia in the Japanese population, although we could not exclude possible contributions of other genes on 22q to the pathogenesis of schizophrenia. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：106 / 112

页数：7

共 52 条

[21] Genome scan meta-analysis of schizophrenia and bipolar disorder, part II:: Schizophrenia [J].

Lewis, CM ;

Levinson, DF ;

Wise, LH ;

DeLisi, LE ;

Straub, RE ;

Hovatta, I ;

Williams, NM ;

Schwab, SG ;

Pulver, AE ;

Faraone, SV ;

Brzustowicz, LM ;

Kaufmann, CA ;

Garver, DL ;

Gurling, HMD ;

Lindholm, E ;

Coon, H ;

Moises, HW ;

Byerley, W ;

Shaw, SH ;

Mesen, A ;

Sherrington, R ;

O'Neill, FA ;

Walsh, D ;

Kendler, KS ;

Ekelund, J ;

Paunio, T ;

Lönnqvist, J ;

Peltonen, L ;

O'Donovan, MC ;

Owen, MJ ;

Wildenauer, DB ;

Maier, W ;

Nestadt, G ;

Blouin, JL ;

Antonarakis, SE ;

Mowry, BJ ;

Silverman, JM ;

Crowe, RR ;

Cloninger, CR ;

Tsuang, MT ;

Malaspina, D ;

Harkavy-Friedman, JM ;

Svrakic, DM ;

Bassett, AS ;

Holcomb, J ;

Kalsi, G ;

McQuillin, A ;

Brynjolfson, J ;

Sigmundsson, T ;

Petursson, H .

AMERICAN JOURNAL OF HUMAN GENETICS, 2003, 73 (01) :34-48

[22] Genetic variation at the 22q11 PRODH2/DGCR6 locus presents an unusual pattern and increases susceptibility to schizophrenia [J].

Liu, H ;

Heath, SC ;

Sobin, C ;

Roos, JL ;

Galke, BL ;

Blundell, ML ;

Lenane, M ;

Robertson, B ;

Wijsman, EM ;

Rapoport, JL ;

Gogos, JA ;

Karayiorgou, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (06) :3717-3722

[23] RASD2, MYH9, and CACNG2 Genes at Chromosome 22q12 Associated with the Subgroup of Schizophrenia with Non-Deficit in Sustained Attention and Executive Function [J].

Liu, Yu-Li ;

Fann, Cathy Shen-Jang ;

Liu, Chih-Min ;

Chen, Wei J. ;

Wu, Jer-Yuarn ;

Hung, Shuen-Iu ;

Chen, Chun-Houh ;

Jou, Yuh-Shan ;

Liu, Shi-Kai ;

Hwang, Tzung-Jeng ;

Hsieh, Ming H. ;

Chang, Chien Ching ;

Yang, Wei-Chih ;

Lin, Jin-Jia ;

Chou, Frank Huang-Chih ;

Faraone, Stephen V. ;

Tsuang, Ming T. ;

Hwu, Hai-Gwo .

BIOLOGICAL PSYCHIATRY, 2008, 64 (09) :789-796

[24] Identification of the semaphorin receptor PLXNA2 as a candidate for susceptibility to schizophrenia [J].

Mah, S ;

Nelson, MR ;

DeLisi, LE ;

Reneland, RH ;

Markward, N ;

James, MR ;

Nyholt, DR ;

Hayward, N ;

Handoko, H ;

Mowry, B ;

Kammerer, S ;

Braun, A .

MOLECULAR PSYCHIATRY, 2006, 11 (05) :471-478

[25] Multicenter linkage study of schizophrenia loci on chromosome 22q [J].

Mowry, BJ ;

Holmans, PA ;

Pulver, AE ;

Gejman, PV ;

Riley, B ;

Williams, NM ;

Laurent, C ;

Schwab, SG ;

Wildenauer, DB ;

Bauché, S ;

Owen, MJ ;

Wormley, B ;

Sanders, AR ;

Nestadt, G ;

Liang, KY ;

Duan, J ;

Ribble, R ;

Norton, N ;

Soubigou, S ;

Maier, W ;

Ewen-White, KR ;

deMarchi, N ;

Carpenter, B ;

Walsh, D ;

Williams, H ;

Jay, M ;

Albus, M ;

Nertney, DA ;

Papadimitriou, G ;

O'Neill, A ;

O'Donovan, MC ;

Deleuze, JF ;

Lerer, FB ;

Dikeos, D ;

Kendler, KS ;

Mallet, J ;

Silverman, JM ;

Crowe, RR ;

Levinson, DF .

MOLECULAR PSYCHIATRY, 2004, 9 (08) :784-795

[26] Genome-wide association study of recurrent major depressive disorder in two European case-control cohorts [J].

Muglia, P. ;

Tozzi, F. ;

Galwey, N. W. ;

Francks, C. ;

Upmanyu, R. ;

Kong, X. Q. ;

Antoniades, A. ;

Domenici, E. ;

Perry, J. ;

Rothen, S. ;

Vandeleur, C. L. ;

Mooser, V. ;

Waeber, G. ;

Vollenweider, P. ;

Preisig, M. ;

Lucae, S. ;

Mueller-Myhsok, B. ;

Holsboer, F. ;

Middleton, L. T. ;

Roses, A. D. .

MOLECULAR PSYCHIATRY, 2010, 15 (06) :589-601

[27] Evidence that the gene encoding ZDHHC8 contributes to the risk of schizophrenia [J].

Mukai, J ;

Liu, H ;

Burt, RA ;

Swor, DE ;

Lai, WS ;

Karayiorgou, M ;

Gogos, JA .

NATURE GENETICS, 2004, 36 (07) :725-731

[28] High rates of schizophrenia in adults with velo-cardio-facial syndrome [J].

Murphy, KC ;

Jones, LA ;

Owen, MJ .

ARCHIVES OF GENERAL PSYCHIATRY, 1999, 56 (10) :940-945

[29] A Genome-Wide Investigation of SNPs and CNVs in Schizophrenia [J].

Need, Anna C. ;

Ge, Dongliang ;

Weale, Michael E. ;

Maia, Jessica ;

Feng, Sheng ;

Heinzen, Erin L. ;

Shianna, Kevin V. ;

Yoon, Woohyun ;

Kasperaviciute, Dalia ;

Gennarelli, Massimo ;

Strittmatter, Warren J. ;

Bonvicini, Cristian ;

Rossi, Giuseppe ;

Jayathilake, Karu ;

Cola, Philip A. ;

McEvoy, Joseph P. ;

Keefe, Richard S. E. ;

Fisher, Elizabeth M. C. ;

St. Jean, Pamela L. ;

Giegling, Ina ;

Hartmann, Annette M. ;

Moeller, Hans-Juergen ;

Ruppert, Andreas ;

Fraser, Gillian ;

Crombie, Caroline ;

Middleton, Lefkos T. ;

St. Clair, David ;

Roses, Allen D. ;

Muglia, Pierandrea ;

Francks, Clyde ;

Rujescu, Dan ;

Meltzer, Herbert Y. ;

Goldstein, David B. .

PLOS GENETICS, 2009, 5 (02)

[30] Meta-analysis of 32 genome-wide linkage studies of schizophrenia [J].

Ng, M. Y. M. ;

Levinson, D. F. ;

Faraone, S. V. ;

Suarez, B. K. ;

DeLisi, L. E. ;

Arinami, T. ;

Riley, B. ;

Paunio, T. ;

Pulver, A. E. ;

Irmansyah ;

Holmans, P. A. ;

Escamilla, M. ;

Wildenauer, D. B. ;

Williams, N. M. ;

Laurent, C. ;

Mowry, B. J. ;

Brzustowicz, L. M. ;

Maziade, M. ;

Sklar, P. ;

Garver, D. L. ;

Abecasis, G. R. ;

Lerer, B. ;

Fallin, M. D. ;

Gurling, H. M. D. ;

Gejman, P. V. ;

Lindholm, E. ;

Moises, H. W. ;

Byerley, W. ;

Wijsman, E. M. ;

Forabosco, P. ;

Tsuang, M. T. ;

Hwu, H-G ;

Okazaki, Y. ;

Kendler, K. S. ;

Wormley, B. ;

Fanous, A. ;

Walsh, D. ;

O'Neill, F. A. ;

Peltonen, L. ;

Nestadt, G. ;

Lasseter, V. K. ;

Liang, K. Y. ;

Papadimitriou, G. M. ;

Dikeos, D. G. ;

Schwab, S. G. ;

Owen, M. J. ;

O'Donovan, M. C. ;

Norton, N. ;

Hare, E. ;

Raventos, H. .

MOLECULAR PSYCHIATRY, 2009, 14 (08) :774-785

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