Novel divergent nidovirus in a python']python with pneumonia

被引：28

作者：

Bodewes, Rogier ^{[1
]}

Lempp, Charlotte ^{[2
]}

Schurch, Anita C. ^{[1
]}

Habierski, Andre ^{[2
]}

Hahn, Kerstin ^{[2
]}

Lamers, Mart ^{[1
]}

von Doernberg, Katja ^{[3
]}

Wohlsein, Peter ^{[2
]}

Drexler, Jan Felix ^{[1
,4
]}

Haagmans, Bart L. ^{[1
]}

Smits, Saskia L. ^{[1
,5
]}

Baumgaertner, Wolfgang ^{[2
]}

Osterhaus, Albert D. M. E. ^{[1
,6
,7
]}

机构：

[1] Erasmus MC, Dept Virosci, Rotterdam, Netherlands

[2] Univ Vet Med, Dept Pathol, Hannover, Germany

[3] Hannover Adventure Zoo, Hannover, Germany

[4] Univ Bonn, Med Ctr, Inst Virol, Bonn, Germany

[5] Viroclin Biosci BV, Rotterdam, Netherlands

[6] Artemis Res Inst Wildlife Hlth, Utrecht, Netherlands

[7] Univ Vet Med, Ctr Infect Med & Zoonoses Res, Hannover, Germany

来源：

JOURNAL OF GENERAL VIROLOGY | 2014年 / 95卷

关键词：

WEB SERVER; VIRUS; RNA; PREDICTION; GENE;

D O I：

10.1099/vir.0.068700-0

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The order Nidovirales contains large, enveloped viruses with a non-segmented positive-stranded RNA genome. Nidoviruses have been detected in man and various animal species, but, to date, there have been no reports of nidovirus in reptiles. In the present study, we describe the detection, characterization, phylogenetic analyses and disease association of a novel divergent nidovirus in the lung of an Indian python (Python molurus) with necrotizing pneumonia. Characterization of the partial genome (>33 000 nt) of this virus revealed several genetic features that are distinct from other nidoviruses, including a very large polyprotein la, a putative ribosomal frameshift signal that was identical to the frameshift signal of astroviruses and retroviruses and an accessory ORF that showed some similarity with the haemagglutinin neuraminidase of parannyxoviruses. Analysis of genome organization and phylogenetic analysis of polyprotein lab suggests that this virus belongs to the subfamily Torovirinae. Results of this study provide novel insights into the genetic diversity within the order Nidovirales.

引用

页码：2480 / 2485

页数：6

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