The Chd family of chromatin remodelers

被引：298

作者：

Marfella, Concetta G. A. ^{[1
]}

Imbalzano, Anthony N. ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Cell Biol, Worcester, MA 01655 USA

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 2007年 / 618卷 / 1-2期

关键词：

chromodomain helicase DNA-binding (CHD) family; ATPase; chromatin remodeling; SNF2; family; transcription elongation; development; differentiation and disease;

D O I：

10.1016/j.mrfmmm.2006.07.012

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Chromatin remodeling enzymes contribute to the dynamic changes that occur in chromatin structure during cellular processes such as transcription, recombination, repair, and replication. Members of the chromodomain helicase DNA-binding (Chd) family of enzymes belong to the SNF2 superfamily of ATP-dependent chromatin remodelers. The Chd proteins are distinguished by the presence of two N-terminal chromodomains that function as interaction surfaces for a variety of chromatin components. Genetic, biochemical, and structural studies demonstrate that Chd proteins are important regulators of transcription and play critical roles during developmental processes. Numerous Chd proteins are also implicated in human disease. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：30 / 40

页数：11

共 88 条

[1]

Aasland R, 1996, TRENDS BIOCHEM SCI, V21, P87, DOI 10.1016/0968-0004(96)30009-1

[2]

AIRIO A, 1995, J RHEUMATOL, V22, P1300

[3] Chromodomains are protein-RNA interaction modules [J].

Akhtar, A ;

Zink, D ;

Becker, PB .

NATURE, 2000, 407 (6802) :405-409

[4] Facts about FACT and transcript elongation through chromatin [J].

Belotserkovskaya, R ;

Reinberg, D .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2004, 14 (02) :139-146

[5] Genomic maps and comparative analysis of histone modifications in human and mouse [J].

Bernstein, BE ;

Kamal, M ;

Lindblad-Toh, K ;

Bekiranov, S ;

Bailey, DK ;

Huebert, DJ ;

McMahon, S ;

Karlsson, EK ;

Kulbokas, EJ ;

Gingeras, TR ;

Schreiber, SL ;

Lander, ES .

CELL, 2005, 120 (02) :169-181

[6] The PHD finger, a nuclear protein-interaction domain [J].

Bienz, M .

TRENDS IN BIOCHEMICAL SCIENCES, 2006, 31 (01) :35-40

[7] AN EXPANDING FAMILY OF HELICASES WITHIN THE DEAD/H SUPERFAMILY [J].

BORK, P ;

KOONIN, EV .

NUCLEIC ACIDS RESEARCH, 1993, 21 (03) :751-752

[8] The dMi-2 chromodomains are DNA binding modules important for ATP-dependent nucleosome mobilization [J].

Bouazoune, K ;

Mitterweger, A ;

Längst, G ;

Imhof, A ;

Akhtar, A ;

Becker, PB ;

Brehm, A .

EMBO JOURNAL, 2002, 21 (10) :2430-2440

[9] Mi-2/NuRD: multiple complexes for many purposes [J].

Bowen, NJ ;

Fujita, N ;

Kajita, M ;

Wade, PA .

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 2004, 1677 (1-3) :52-57

[10] The SANT domain: a unique histone-tail-binding module? [J].

Boyer, LA ;

Latek, RR ;

Peterson, CL .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2004, 5 (02) :158-163

← 1 2 3 4 5 6 7 8 9 →