Impact of calcified bifurcation lesions in patients undergoing percutaneous coronary intervention using drug-eluting stents: results from the COronary BIfurcation Stent (COBIS) II registry

被引：26

作者：

Kim, Min Chul ^{[1
]}

Ahn, Youngkeun ^{[1
]}

Sim, Doo Sun ^{[1
]}

Hong, Young Joon ^{[1
]}

Kim, Ju Han ^{[1
]}

Jeong, Myung Ho ^{[1
]}

Gwon, Hyeon-Cheol ^{[2
]}

Kim, Hyo-Soo ^{[3
]}

Rha, Seung Woon ^{[4
]}

Yoon, Jung Han ^{[5
]}

Jang, Yangsoo ^{[6
]}

Tahk, Seung-Jea ^{[7
]}

Seung, Ki Bea ^{[8
]}

机构：

[1] Chonnam Natl Univ Hosp, Dept Cardiol, Gwangju, South Korea

[2] Sungkyunkwan Univ, Sch Med, Dept Cardiol, Samsung Med Ctr, Seoul, South Korea

[3] Seoul Natl Univ Hosp, Dept Cardiol, Seoul, South Korea

[4] Korea Univ, Guro Hosp, Dept Cardiol, Seoul, South Korea

[5] Wonju Christian Hosp, Dept Cardiol, Wonju, South Korea

[6] Yonsei Univ, Severance Hosp, Dept Cardiol, Seoul, South Korea

[7] Ajou Univ Hosp, Dept Cardiol, Suwon, South Korea

[8] Catholic Univ Kangnam, Dept Cardiol, Seoul, South Korea

来源：

EUROINTERVENTION | 2017年 / 13卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

bifurcation lesion; coronary calcification; drug-eluting stent; percutaneous coronary intervention; ACUTE MYOCARDIAL-INFARCTION; PROGNOSTIC IMPLICATIONS; HARMONIZING OUTCOMES; POOLED ANALYSIS; CALCIFICATION; TRIALS; REVASCULARIZATION; DISEASE;

D O I：

10.4244/EIJ-D-16-00264

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims: Few data regarding clinical outcomes according to severity of calcification in patients with coronary bifurcation target lesions are available. We therefore aimed to evaluate the clinical outcomes according to severity of calcification in patients with coronary bifurcation target lesions after percutaneous coronary intervention (PCI) with drug-eluting stents (DES) using a large-scale multicentre Korean registry. Methods and results: This prospective, multicentre, observational registry enrolled 2,897 patients undergoing PCI with DES for coronary bifurcation lesions. We compared target lesion failure (TLF), defined as a composite of cardiac death, non-fatal myocardial infarction (MI). and target lesion revascularisation (TER), according to severity of calcification in corollary bifurcation target lesions, assessed by an angiographic core laboratory using quantitative corollary angiography. Moderate or severe calcification of target bifurcation lesions was observed in 608 (20.9%) patients. During a median follow-up period of 36 months, moderate or severe calcification increased the adjusted risks of TLF (hazard ratio [FIRI 1.31, 95% confidence interval [CI]: 1.03-1.68. p=0.031), TER (FIR 1.36, 95% CI: 1.04-1.79, p=0.027), and revascularisation (HR 1.39, 95% CT: 1.09-1.78, 1)=0.009). However, it was not associated with an increased risk of cardiac death, MI, or stent thrombosis. Conclusions: Moderate or severe calcification of coronary bifurcation lesions is not uncommon and is associated with unfavourable long-term clinical outcomes, driven mainly by an increased frequency of repeat revascularisation.

引用

页码：338 / 344

页数：7