Tissue factor, protease activated receptors and pathologic heart remodelling

被引：26
作者：
Antoniak, Silvio [1 ]
Sparkenbaugh, Erica [1 ]
Pawlinski, Rafal [1 ]
机构：
[1] Univ N Carolina, Dept Med, Div Hematol & Oncol, McAllister Heart Inst, Chapel Hill, NC 27599 USA
来源：
THROMBOSIS AND HAEMOSTASIS | 2014年 / 112卷 / 05期
基金：
美国国家卫生研究院;
关键词：
MYOCARDIAL ISCHEMIA/REPERFUSION INJURY; ISCHEMIA-REPERFUSION INJURY; INNATE IMMUNE-RESPONSE; COAGULATION-FACTOR XA; FACTOR EXPRESSION; VIRAL MYOCARDITIS; CARDIAC FIBROSIS; BLOOD PRESSURES; VIRUS-INFECTION; MULTIPLE ROLES;
D O I：
10.1160/TH14-03-0243
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Tissue factor is the primary initiator of coagulation cascade and plays an essential role in haemostasis and thrombosis. In addition, tissue factor and coagulation proteases contribute to many cellular responses via activation of protease activated receptors. The heart is an organ with high levels of constitutive tissue factor expression. This review focuses on the role of tissue factor, coagulation proteases and protease activated receptors in heart haemostasis and the pathological heart remodelling associated with myocardial infarction, viral myocarditis and hypertension.
引用
收藏
页码：893 / 900
页数：8
相关论文
共 99 条
[1]   Coagulation and fibrinolytic parameters in patients with pulmonary hypertension [J].
Altman, R ;
Scazziota, A ;
Rouvier, J ;
Gurfinkel, E ;
Favaloro, R ;
Perrone, S ;
Fareed, J .
CLINICAL CARDIOLOGY, 1996, 19 (07) :549-554
[2]   Regulation of cardiomyocyte full-length tissue factor expression and microparticle release under inflammatory conditions in vitro [J].
Antoniak, S. ;
Boltzen, U. ;
Eisenreich, A. ;
Stellbaum, C. ;
Poller, W. ;
Schultheiss, H. P. ;
Rauch, U. .
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2009, 7 (05) :871-878
[3]   Viral myocarditis and coagulopathy:: Increased tissue factor expression and plasma thrombogenicity [J].
Antoniak, Silvio ;
Boltzen, Ulrike ;
Riad, Alexander ;
Kallwellis-Opara, Angela ;
Rohde, Maria ;
Doerner, Andrea ;
Tschoepe, Carsten ;
Noutsias, Michel ;
Pauschinger, Matthias ;
Schultheiss, Heinz-Peter ;
Rauch, Ursula .
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2008, 45 (01) :118-126
[4]   Multiple roles of the coagulation protease cascade during virus infection [J].
Antoniak, Silvio ;
Mackman, Nigel .
BLOOD, 2014, 123 (17) :2605-2613
[5]   Coagulation, Protease-Activated Receptors, and Viral Myocarditis [J].
Antoniak, Silvio ;
Mackman, Nigel .
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, 2014, 7 (02) :203-211
[6]   Protease Activated Receptor-2 Contributes to Heart Failure [J].
Antoniak, Silvio ;
Sparkenbaugh, Erica M. ;
Tencati, Michael ;
Rojas, Mauricio ;
Mackman, Nigel ;
Pawlinski, Rafal .
PLOS ONE, 2013, 8 (11)
[7]   PAR-1 contributes to the innate immune response during viral infection [J].
Antoniak, Silvio ;
Owens, A. Phillip, III ;
Baunacke, Martin ;
Williams, Julie C. ;
Lee, Rebecca D. ;
Weithaeuser, Alice ;
Sheridan, Patricia A. ;
Malz, Ronny ;
Luyendyk, James P. ;
Esserman, Denise A. ;
Trejo, JoAnn ;
Kirchhofer, Daniel ;
Blaxall, Burns C. ;
Pawlinski, Rafal ;
Beck, Melinda A. ;
Rauch, Ursula ;
Mackman, Nigel .
JOURNAL OF CLINICAL INVESTIGATION, 2013, 123 (03) :1310-1322
[8]   Protease-activated Receptors and Myocardial Infarction [J].
Antoniak, Silvio ;
Pawlinski, Rafal ;
Mackman, Nigel .
IUBMB LIFE, 2011, 63 (06) :383-389
[9]   Protease-Activated Receptor 2 Deficiency Reduces Cardiac Ischemia/Reperfusion Injury [J].
Antoniak, Silvio ;
Rojas, Mauricio ;
Spring, Denise ;
Bullard, Tara A. ;
Verrier, Edward D. ;
Blaxall, Burns C. ;
Mackman, Nigel ;
Pawlinski, Rafal .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2010, 30 (11) :2136-2142
[10]   Matrix metalloproteases and PAR1 activation [J].
Austin, Karyn M. ;
Covic, Lidija ;
Kuliopulos, Athan .
BLOOD, 2013, 121 (03) :431-439
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