Synthesis and Properties of New Fluorine-Containing Thieno[2,3-b]pyridine Derivatives

被引：7

作者：

Buryi, D. S. ^{[1
]}

Dotsenko, V. V. ^{[1
,2
]}

Aksenov, N. A. ^{[2
]}

Aksenova, I. V. ^{[2
]}

机构：

[1] Kuban State Univ, Krasnodar 350040, Russia

[2] North Caucasian Fed Univ, Stavropol, Russia

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2019年 / 89卷 / 09期

基金：

俄罗斯基础研究基金会;

关键词：

cyanothioacetamide; Guareschi-Thorpe reaction; Thorpe-Ziegler cyclization; thieno[2; 3-b]pyridines; in silico biological activity; organic fluorides; ONE-POT SYNTHESIS; REGIOSELECTIVE SYNTHESIS; ESTIMATE SOLUBILITY; DRUG DISCOVERY; PERMEABILITY; HETEROCYCLES; CRYSTAL;

D O I：

10.1134/S1070363219090032

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cyanothioacetamide reacted with 1,1,5,5-tetrafluoroacetylacetone to give 4,6-bis(difluoromethyl)-2-thioxo-1,2-dihydropyridine-3-carbonitrile, and alkylation of the latter with alpha-chloroacetamides afforded 3-amino-4,6-bis(difluoromethyl)thieno[2,3-b]pyridine-2-carboxamides. The structure of the key compounds was proved using two-dimensional NMR techniques. In silico analysis of potential biological activity and bioavailability of the synthesized compounds was performed.

引用

页码：1744 / 1751

页数：8

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