Antioxidants in health and disease

被引:68
作者
Ginter, E. [1 ]
Simko, V [2 ]
Panakova, V [1 ]
机构
[1] Slovak Med Univ, Bratislava, Slovakia
[2] Suny Downstate Med Ctr, Brooklyn, NY 11203 USA
来源
BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY | 2014年 / 115卷 / 10期
关键词
reactive oxygen species (ROS); antioxidants; vitamin C and E; carotenoids; polyphenols; immune modulation; nitric oxide (NO); bioavailability; resveratrol; feruloylnoradrenaline; OXIDATIVE STRESS; VITAMIN-C; CAROTENOIDS; SUPPLEMENTATION; METAANALYSIS; ASTAXANTHIN; RESVERATROL; POLYPHENOLS; PREVENTION; PHYSIOLOGY;
D O I
10.4149/BLL_2014_116
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Research on antioxidants proceeds at full speed after a partial decline of public interest, when claims on effectiveness of mega doses of vitamin C proved unfounded. The main role of antioxidants is to liquidate the uncontrolled production of reactive oxygen species (ROS) that is being linked to pathogenesis of cardiovascular disease (CVD), malignancy, diabetes type 2, mechanism of infection, fibrogenesis and some neurological disorders. This review summarizes the most recent reports on antioxidants, published since 2010. Follow up data on vitamins C and E focus on their potential for immune modulation and on endothelial nitric oxide bioavailability. Previously well established antioxidants carotenoids and polyphenols are still much in scientific interest. Interestingly, several antioxidants (for example rasveratrol and feruloylnoradrenaline) are generated in infected or injured plants. An intensive attention is directed to resveratrol. This compound, in addition to antioxidation, stimulates nitric oxid production, protects endothelial cells from oxidative functional damage, lowers platelet aggregation and directly inhibits cyclic adenosine monophosphate-specific phosphodiesterases. Recently discovered feruloylnoradrenaline in microbially infected tomatoes is reported to have 14 times the antioxidant power of resveratrol. With all this new information, it is important to point out the prevailing opinion that additional supplements of antioxidants are not needed, as long as the organism has adequate stores of antioxidants and the diet is normal in composition and in quantity (Fig. 3, Ref. 34). Text in PDF www.elis.sk.
引用
收藏
页码:603 / 606
页数:4
相关论文
共 32 条
[1]   Effects of Oral Glutathione Supplementation on Systemic Oxidative Stress Biomarkers in Human Volunteers [J].
Allen, Jason ;
Bradley, Ryan D. .
JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE, 2011, 17 (09) :827-833
[2]   Wine, Beer, Alcohol and Polyphenols on Cardiovascular Disease and Cancer [J].
Arranz, Sara ;
Chiva-Blanch, Gemma ;
Valderas-Martinez, Palmira ;
Medina-Remon, Alex ;
Lamuela-Raventos, Rosa M. ;
Estruch, Ramon .
NUTRIENTS, 2012, 4 (07) :759-781
[3]   Dietary compared with blood concentrations of carotenoids and breast cancer risk: a systematic review and meta-analysis of prospective studies [J].
Aune, Dagfinn ;
Chan, Doris S. M. ;
Vieira, Ana Rita ;
Rosenblatt, Deborah A. Navarro ;
Vieira, Rui ;
Greenwood, Darren C. ;
Norat, Teresa .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2012, 96 (02) :356-373
[4]   The Properties, Functions, and Use of Selenium Compounds in Living Organisms [J].
Bodnar, Malgorzata ;
Konieczka, Piotr ;
Namiesnik, Jacek .
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS, 2012, 30 (03) :225-252
[5]  
Böhm F, 2012, ACTA BIOCHIM POL, V59, P27
[6]   Redox Signaling in Cardiac Physiology and Pathology [J].
Burgoyne, Joseph R. ;
Mongue-Din, Heloise ;
Eaton, Philip ;
Shah, Ajay M. .
CIRCULATION RESEARCH, 2012, 111 (08) :1091-1106
[7]   Plasma Vitamin C Concentrations in Patients on Routine Hemodialysis and its Relationship to Patients' Morbidity and Mortality [J].
Dashti-Khavidaki, Simin ;
Talasaz, Azita Hajhossein ;
Tabeefar, Hamed ;
Hajimahmoodi, Mannan ;
Moghaddam, Ghazaleh ;
Khalili, Hossein ;
Lessan-Pezeshki, Mahboob ;
Jahanmardi, Afsaneh .
INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH, 2011, 81 (04) :197-203
[8]   Ascorbic acid: Chemistry, biology and the treatment of cancer [J].
Du, Juan ;
Cullen, Joseph J. ;
Buettner, Garry R. .
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2012, 1826 (02) :443-457
[9]   Authors' Perspective: What is the Optimum Intake of Vitamin C in Humans? [J].
Frei, Balz ;
Birlouez-Aragon, Ines ;
Lykkesfeldt, Jens .
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, 2012, 52 (09) :815-829
[10]   Plant polyphenols in prevention of heart disease [J].
Ginter, E. ;
Simko, V .
BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, 2012, 113 (08) :476-480