A porphyrin-basesd fluorescent probe for optical detection of toxic Cd2+ ion in aqueous solution and living cells

被引：54
作者：
Huang, Wen-Bin [1 ,2 ]
Gu, Wei [1 ,2 ]
Huang, Hong-Xia [1 ]
Wang, Jun-Bo [1 ]
Shen, Wang-Xing [1 ]
Lv, Yuan-Yuan [1 ]
Shen, Jie [1 ]
机构：
[1] Zhejiang Univ City Coll, Sch Med, Hangzhou 310015, Zhejiang, Peoples R China
[2] Zhejiang Univ, Coll Chem & Biol Engn, Hangzhou 310027, Zhejiang, Peoples R China
来源：
DYES AND PIGMENTS | 2017年 / 143卷
基金：
美国国家科学基金会;
关键词：
Cadmium ion; Porphyrin; Fluorescent chemosensor; Ratiometric sensor; Intramolecular charge transfer (ICT); Cell imaging; PHYSIOLOGICAL PH; CADMIUM IONS; ZINC IONS; EMISSION-SPECTROMETRY; SENSOR; CHEMOSENSOR; ZN2+; WATER; SHIFT; HG2+;
D O I：
10.1016/j.dyepig.2017.05.001
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A porphyrin-based water-soluble fluorescent probe was reported for ratiometric detection of cadmium ion (Cd2+) in aqueous solution. This probe bearing two 2,2'-dipyridylamine (DPA) groups as metal chelating moieties which show chelation-produced ratiometric fluorescence effect with Cd2+ via the interruption of intramolecular charge transfer (ICT) process. Exhibiting a large ratiometric fluorescence signal, the probe shows high sensitivity, high selectivity as well as quick response when detecting Cd2+ in the physiological pH window with a detection limit of part per billion (ppb) level. Moreover, it displays very low cytotoxicity and can be employed to visualize intracellular Cd2+ in living cells by utilizing laser scanning confocal microscopy. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：427 / 435
页数：9
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