Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis

被引：219

作者：

DeBosch, Brian J. ^{[1
]}

Heitmeier, Monique R. ^{[1
]}

Mayer, Allyson L. ^{[1
]}

Higgins, Cassandra B. ^{[1
]}

Crowley, Jan R. ^{[2
]}

Kraft, Thomas E. ^{[1
]}

Chi, Maggie ^{[3
]}

Newberry, Elizabeth P. ^{[2
]}

Chen, Zhouji ^{[2
]}

Finck, Brian N. ^{[2
]}

Davidson, Nicholas O. ^{[2
]}

Yarasheski, Kevin E. ^{[2
]}

Hruz, Paul W. ^{[1
]}

Moley, Kelle H. ^{[3
]}

机构：

[1] Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, Dept Obstet & Gynecol, St Louis, MO 63110 USA

来源：

SCIENCE SIGNALING | 2016年 / 9卷 / 416期

关键词：

GLUCOSE TRANSPORTERS; INSULIN; CHREBP;

D O I：

10.1126/scisignal.aac5472

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Trehalose is a naturally occurring disaccharide that has gained attention for its ability to induce cellular autophagy and mitigate diseases related to pathological protein aggregation. Despite decades of ubiquitous use as a nutraceutical, preservative, and humectant, its mechanism of action remains elusive. We showed that trehalose inhibited members of the SLC2A (also known as GLUT) family of glucose transporters. Trehalose-mediated inhibition of glucose transport induced AMPK (adenosine 5'-monophosphate-activated protein kinase)-dependent autophagy and regression of hepatic steatosis in vivo and a reduction in the accumulation of lipid droplets in primary murine hepatocyte cultures. Our data indicated that trehalose triggers beneficial cellular autophagy by inhibiting glucose transport.

引用

页数：13

共 36 条

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