Linking the YTH domain to cancer: the importance of YTH family proteins in epigenetics

被引：67
作者：
Shi, Rongkai [1 ]
Ying, Shilong [1 ]
Li, Yadan [1 ]
Zhu, Liyuan [1 ]
Wang, Xian [2 ]
Jin, Hongchuan [1 ]
机构：
[1] Zhejiang Univ, Sir Run Run Shaw Hosp, Key Lab Biotherapy Zhejiang, Lab Canc Biol,Canc Ctr, Hangzhou, Peoples R China
[2] Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Med Oncol, Sch Med, Hangzhou, Peoples R China
来源：
CELL DEATH & DISEASE | 2021年 / 12卷 / 04期
关键词：
MESSENGER-RNA METHYLATION; GENOME-WIDE IDENTIFICATION; BINDING-PROTEIN; NUCLEAR-RNA; M(6)A RNA; CRYSTAL-STRUCTURE; STRUCTURAL BASIS; HELICASE YTHDC2; READER; N-6-METHYLADENOSINE;
D O I：
10.1038/s41419-021-03625-8
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
N6-methyladenosine (m6A), the most prevalent and reversible modification of mRNA in mammalian cells, has recently been extensively studied in epigenetic regulation. YTH family proteins, whose YTH domain can recognize and bind m6A-containing RNA, are the main "readers" of m6A modification. YTH family proteins perform different functions to determine the metabolic fate of m6A-modified RNA. The crystal structure of the YTH domain has been completely resolved, highlighting the important roles of several conserved residues of the YTH domain in the specific recognition of m6A-modified RNAs. Upstream and downstream targets have been successively revealed in different cancer types and the role of YTH family proteins has been emphasized in m6A research. This review describes the regulation of RNAs by YTH family proteins, the structural features of the YTH domain, and the connections of YTH family proteins with human cancers.
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页数：14
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