HIV-1 Langerhans' cell tropism associated with heterosexual transmission of HIV

被引：283

作者：

SotoRamirez, LE

Renjifo, B

McLane, MF

Marlink, R

OHara, C

Sutthent, R

Wasi, C

Vithayasai, P

Vithayasai, V

Apichartpiyakul, C

Auewarakul, P

Cruz, VP

Chui, DS

Osathanondh, R

Mayer, K

Lee, TH

Essex, M

机构：

[1] HARVARD AIDS INST,BOSTON,MA 02115

[2] MALLORY INST PATHOL,BOSTON,MA 02118

[3] MAHIDOL UNIV,SIRIRAJ HOSP,FAC MED,DEPT MICROBIOL,BANGKOK 10700,THAILAND

[4] CHIANG MAI UNIV,FAC MED,DEPT MICROBIOL,CHIANG MAI 50002,THAILAND

[5] BRIGHAM & WOMENS HOSP,DEPT OBSTET & GYNECOL,BOSTON,MA 02115

[6] FENWAY COMMUNITY HLTH CTR,RES DEPT,BOSTON,MA 02115

[7] MEM HOSP RHODE ISL,DEPT MED,DIV INFECT DIS,PAWTUCKET,RI 02860

[8] BROWN UNIV,SCH MED,PROVIDENCE,RI 02912

来源：

SCIENCE | 1996年 / 271卷 / 5253期

关键词：

D O I：

10.1126/science.271.5253.1291

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Heterosexual transmission by vaginal intercourse accounts for most transmission of human immunodeficiency virus-type 1 (HIV-1) in Africa and Asia but is less important in the HIV-1 epidemics of the United States and Western Europe. Epithelial Langerhans' cells (LCs) represent a possible source of initial cell contact for vaginal infection. Fifteen primary isolates of HIV-1 from U.S. homosexuals and 18 HIV-1 isolates from Thailand heterosexuals were evaluated for growth in LCs of U.S. origin. All the viruses from the Thai heterosexuals, which were subtype E, grew more efficiently in the LCs than any of the viruses from the U.S. homosexuals, which are subtype B. These results suggest that LC tropism is associated with the efficiency of heterosexual transmission of HIV.

引用

页码：1291 / 1293

页数：3

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