Radiation exposure triggers the progression of triple negative breast cancer via stabilizing ZEB1

被引：8
作者：
Lin, Yu [1 ]
Bai, Xia [2 ]
Zhou, Weina [2 ]
He, Yulin [2 ]
Wu, Yiwei [3 ]
Wang, Xiangcheng [2 ]
机构：
[1] Inner Mongolia Med Univ, Dept Ontol Radiotherapy, Affiliated Hosp, Hohhot, Inner Mongolia, Peoples R China
[2] Inner Mongolia Med Univ, Dept Nucl Med, Affiliated Hosp, Hohhot 010050, Inner Mongolia, Peoples R China
[3] Soochow Univ, Affiliated Hosp 1, Dept Nucl Med, Suzhou 215000, Jiangsu, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2018年 / 107卷
关键词：
Radiation; TNBC; ZEB1; ATM; Migration; EPITHELIAL-MESENCHYMAL TRANSITION; TRANSCRIPTION FACTORS; CELLS; CARCINOMA; RADIOTHERAPY; EXPRESSION; STRATEGIES; INVASION; PATHWAY; EMT;
D O I：
10.1016/j.biopha.2018.08.026
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Our present study confirmed radiation can promote the in vitro migration and invasion of triple negative breast cancer (TNBC) cells and increase the expression of epithelial-mesenchymal transition (EMT) related transcription factor ZEB1, while had no effect on Snail, Slug or Twist. Knockdown of ZEB1 attenuated radiation induced cell migration and invasion, suggesting that ZEB1 is essential for radiation induced progression of TNBC. Radiation increased the protein stability of ZEB1, while had no effect on its mRNA expression. Particularly, the upregulation of ATM, which can phosphorylate and stabilize ZEB1, was involved in radiation induced upregulation of ZEB1. Collectively, we found that radiation can promote the migration, invasion and EMT of TNBC cells through stabilization of ZEB1 via ATM signals.
引用
收藏
页码：1624 / 1630
页数：7
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