A stereoselective synthesis of 1,3,4-substituted β-lactams from polymer-supported chiral oxazolidine aldehyde

被引：29

作者：

Gordon, K ^{[1
]}

Bolger, M ^{[1
]}

Khan, N ^{[1
]}

Balasubramanian, S ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 44期

基金：

英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

polymer support; chiral aldehyde; beta-lactam; oxazolidine;

D O I：

10.1016/S0040-4039(00)01516-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of a polymer supported chiral oxazolidine aldehyde is described. This intermediate has great potential for the synthesis of biologically interesting compounds. A solid phase stereoselective synthesis of an array of chirally pure S-lactams in high purity is described as a first application of the system. (C) 2000 Elsevier Science Ltd. All rights reserved.

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收藏

页码：8621 / 8625

页数：5

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