Fusion with the fused:: A new role for interleukin-4 in the building of muscle

被引：15

作者：

Chargé, S ^{[1
]}

Rudnicki, MA ^{[1
]}

机构：

[1] Ottawa Hlth Res Inst, Program Mol Med, Ottawa, ON K1H 8L6, Canada

来源：

CELL | 2003年 / 113卷 / 04期

关键词：

D O I：

10.1016/S0092-8674(03)00358-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this issue of Cell, G. Pavlath and coworkers (Horsley et al., 2003) demonstrate a novel role for Interleukin-4 (IL-4) in regulating the fusion of myoblasts with differentiated myotubes. The authors demonstrate that NFATc2 signaling in newly formed myotubes induces IL-4 expression and secretion which promotes myoblast fusion with pre-existing myotubes.

引用

页码：422 / 423

页数：2

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