Hematopoietic Stem Cell Transplantation for Primary Immunodeficiencies

被引：14
作者：
Kang, Elizabeth [1 ]
Gennery, Andrew [2 ]
机构：
[1] NIAID, Hematotherapeut Unit, Lab Host Def, NIH, Bethesda, MD 20892 USA
[2] Great North Childrens Hosp, Inst Cellular Med, Paediat Immunol Dept, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England
来源：
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2014年 / 28卷 / 06期
关键词：
Immunodeficiency; Immune reconstitution; Infection; Immunosuppression; Inflammation; BONE-MARROW-TRANSPLANTATION; CHRONIC GRANULOMATOUS-DISEASE; WISKOTT-ALDRICH-SYNDROME; TERM IMMUNE RECONSTITUTION; IN-UTERO TRANSPLANTATION; SINGLE-CENTER EXPERIENCE; DOCK8; DEFICIENCY; HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS; EUROPEAN EXPERIENCE; FANCONI-ANEMIA;
D O I：
10.1016/j.hoc.2014.08.006
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Allogeneic hematopoietic stem cell transplantation has been shown to be curative for well-described as well as newly discovered immunodeficiencies. However, it is difficult to define a universal transplant regimen given the rarity of these disorders and the varied pathophysiology these disorders encompass. This article discusses those primary immunodeficiencies most commonly treated by hematopoietic stem cell transplant and describes the transplant issues specific to these disorders.
引用
收藏
页码：1157 / +
页数：15
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