Free Fatty Acid Receptors in Enteroendocrine Cells

被引：53

作者：

Lu, Van B. ^{[1
,2
]}

Gribble, Fiona M. ^{[1
,2
]}

Reimann, Frank ^{[1
,2
]}

机构：

[1] Addenbrookes Hosp, Inst Metab Sci, Metab Res Labs, Hills Rd, Cambridge CB2 0QQ, England

[2] Addenbrookes Hosp, Inst Metab Sci, Med Res Council, Metab Dis Unit, Hills Rd, Cambridge CB2 0QQ, England

来源：

ENDOCRINOLOGY | 2018年 / 159卷 / 07期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

PROTEIN-COUPLED-RECEPTOR; GLUCAGON-LIKE PEPTIDE-1; GASTRIC GHRELIN CELLS; UPPER SMALL-INTESTINE; HUMAN-COLON; GIP SECRETION; K CELLS; FUNCTIONAL-CHARACTERIZATION; GASTROINTESTINAL-TRACT; INCRETIN SECRETION;

D O I：

10.1210/en.2018-00261

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Free fatty acid receptors (FFAs) are highly enriched in enteroendocrine cells providing pathways to link dietary fats and microbially generated short-chain fatty acids (SCFAs) to the secretion of a variety of gut hormones. FFA1 and FFA4 are receptors for long-chain fatty acids that have been linked to the elevation of plasma gut hormones after fat ingestion. FFA2 and FFA3 are receptors for SCFA, which are generated at high concentrations by microbial fermentation of dietary fiber and have also been implicated in enhancement of gut hormone secretion. FFAs are candidate drug targets for increasing the secretion of intestinal hormones such as glucagon-like peptide-1 and peptide YY as potential new treatments for type 2 diabetes and obesity. This review will examine aspects of intestinal physiology and pharmacology related to the function of FFAs in enteroendocrine cells.

引用

页码：2826 / 2835

页数：10

共 88 条

[1] Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways [J].

Bellono, Nicholas W. ;

Bayrer, James R. ;

Leitch, Duncan B. ;

Castro, Joel ;

Zhang, Chuchu ;

O'Donnell, Tracey A. ;

Brierley, Stuart M. ;

Ingraham, Holly A. ;

Julius, David .

CELL, 2017, 170 (01) :185-198.e16

[2] Improved glucose control and reduced body fat mass in free fatty acid receptor 2-deficient mice fed a high-fat diet [J].

Bjursell, Mikael ;

Admyre, Therese ;

Goransson, Melker ;

Marley, Anna E. ;

Smith, David M. ;

Oscarsson, Jan ;

Bohlooly-Y, Mohammad .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2011, 300 (01) :E211-E220

[3] A Novel Allosteric Activator of Free Fatty Acid 2 Receptor Displays Unique Gi-functional Bias [J].

Bolognini, Daniele ;

Moss, Catherine E. ;

Nilsson, Karolina ;

Petersson, Annika U. ;

Donnelly, Iona ;

Sergeev, Eugenia ;

Koenig, Gabriele M. ;

Kostenis, Evi ;

Kurowska-Stolarska, Mariola ;

Miller, Ashley ;

Dekker, Niek ;

Tobin, Andrew B. ;

Milligan, Graeme .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 291 (36) :18915-18931

[4] The Pharmacology and Function of Receptors for Short-Chain Fatty Acids [J].

Bolognini, Daniele ;

Tobin, Andrew B. ;

Milligan, Graeme ;

Moss, Catherine E. .

MOLECULAR PHARMACOLOGY, 2016, 89 (03) :388-398

[5] Mechanisms to Elevate Endogenous GLP-1 Beyond Injectable GLP-1 Analogs and Metabolic Surgery [J].

Briere, Daniel A. ;

Bueno, Ana B. ;

Gunn, Ellen J. ;

Michael, M. Dodson ;

Sloop, Kyle W. .

DIABETES, 2018, 67 (02) :309-320

[6] The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids [J].

Briscoe, CP ;

Tadayyon, M ;

Andrews, JL ;

Benson, WG ;

Chambers, JK ;

Eilert, MM ;

Ellis, C ;

Elshourbagy, NA ;

Goetz, AS ;

Minnick, DT ;

Murdock, PR ;

Sauls, HR ;

Shabon, U ;

Spinage, LD ;

Strum, JC ;

Szekeres, PG ;

Tan, KB ;

Way, JM ;

Ignar, DM ;

Wilson, S ;

Muir, AI .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (13) :11303-11311

[7] Fermentable carbohydrate stimulates FFAR2-dependent colonic PYY cell expansion to increase satiety [J].

Brooks, Lucy ;

Viardot, Alexander ;

Tsakmaki, Anastasia ;

Stolarczyk, Emilie ;

Howard, Jane K. ;

Cani, Patrice D. ;

Everard, Amandine ;

Sleeth, Michelle L. ;

Psichas, Arianna ;

Anastasovskaj, Jelena ;

Bell, Jimmy D. ;

Bell-Anderson, Kim ;

Mackay, Charles R. ;

Ghatei, Mohammad A. ;

Bloom, Stephen R. ;

Frost, Gary ;

Bewick, Gavin A. .

MOLECULAR METABOLISM, 2017, 6 (01) :48-60

[8] The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids [J].

Brown, AJ ;

Goldsworthy, SM ;

Barnes, AA ;

Eilert, MM ;

Tcheang, L ;

Daniels, D ;

Muir, AI ;

Wigglesworth, MJ ;

Kinghorn, I ;

Fraser, NJ ;

Pike, NB ;

Strum, JC ;

Steplewski, KM ;

Murdock, PR ;

Holder, JC ;

Marshall, FH ;

Szekeres, PG ;

Wilson, S ;

Ignar, DM ;

Foord, SM ;

Wise, A ;

Dowell, SJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (13) :11312-11319

[9] Dietary non-digestible carbohydrates promote L-cell differentiation in the proximal colon of rats [J].

Cani, Patrice D. ;

Hoste, Sophie ;

Guiot, Yves ;

Delzenne, Nathalie M. .

BRITISH JOURNAL OF NUTRITION, 2007, 98 (01) :32-37

[10]

Christensen LW, 2015, PHYSL REP, V3, P1

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