Natural product total synthesis using rearrangement reactions

被引：24

作者：

Chen, Lu ^{[1
,3
]}

Li, Guang ^{[2
]}

Zu, Liansuo ^{[3
]}

机构：

[1] Fujian Agr & Forestry Univ, Coll Plant Protect, Key Lab Biopesticide & Chem Biol, Minist Educ, Fuzhou 350002, Fujian, Peoples R China

[2] Peking Union Med Coll & Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China

[3] Tsinghua Univ, Sch Pharmaceut Sci, Beijing 100084, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2022年 / 9卷 / 19期

基金：

中国国家自然科学基金;

关键词：

ENANTIOSELECTIVE TOTAL SYNTHESES; SKELETAL REARRANGEMENTS; AKUAMMILINE ALKALOIDS; COLLECTIVE SYNTHESES; A-C; DISCOVERY;

D O I：

10.1039/d2qo01040b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Total synthesis of natural products has been an important pursuit in chemical synthesis due to their fascinating structural complexity and/or interesting biological activities. In most synthetic designs, the rapid construction of the core skeletons, the precise control of stereochemistry, and the identification of suitable synthons are key concerns, which, to a large extent, account for the overall synthetic efficiency. This review will highlight how rearrangement reactions can contribute in addressing these three concerns, thus simplifying the total synthesis campaigns.

引用

页码：5383 / 5394

页数：12

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