Infectivity of Post-Kala-azar Dermal Leishmaniasis Patients to Sand Flies: Revisiting a Proof of Concept in the Context of the Kala-azar Elimination Program in the Indian Subcontinent

被引：61

作者：

Molina, Ricardo ^{[1
]}

Ghosh, Debashis ^{[2
]}

Carrillo, Eugenia ^{[3
]}

Monnerat, Severine ^{[4
]}

Bern, Caryn ^{[5
]}

Mondal, Dinesh ^{[2
]}

Alvar, Jorge ^{[4
]}

机构：

[1] Inst Salud Carlos III, World Hlth Org Collaborating Ctr Leishmaniasis, Lab Med Entomol, Natl Ctr Microbiol, Madrid, Spain

[2] Int Ctr Diarrhoeal Dis Res, Dhaka, Bangladesh

[3] Inst Salud Carlos III, World Hlth Org Collaborating Ctr Leishmaniasis, Natl Ctr Microbiol, Lab Leishmaniasis & Chagas, Madrid, Spain

[4] Drugs Neglected Dis Initiat, 15 Chemin Louis Dunant, CH-1202 Geneva, Switzerland

[5] Univ Calif San Francisco, Sch Med, Dept Epidemiol & Biostat, San Francisco, CA USA

来源：

CLINICAL INFECTIOUS DISEASES | 2017年 / 65卷 / 01期

关键词：

leishmaniasis; post-kala-azar dermal leishmaniasis; control; xenodiagnosis; INFANTUM;

D O I：

10.1093/cid/cix245

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We compared xenodiagnosis with quantitative polymerase chain reaction in skin biopsies from 3 patients with maculopapular or nodular post-kala-azar dermal leishmaniasis (PKDL). All patients infected sand flies. Parasite loads in skin varied from 1428 to 63 058 parasites per microgram. PKDL detection and treatment are important missing components of the kala-azar elimination program.

引用

页码：150 / 153

页数：4

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