A Hyaluronic Acid Functionalized Self-Nano-Emulsifying Drug Delivery System (SNEDDS) for Enhancement in Ciprofloxacin Targeted Delivery against Intracellular Infection

被引：52

作者：

Arshad, Rabia ^{[1
]}

Tabish, Tanveer A. ^{[2
]}

Kiani, Maria Hassan ^{[1
]}

Ibrahim, Ibrahim M. ^{[3
]}

Shahnaz, Gul ^{[1
]}

Rahdar, Abbas ^{[4
]}

Kang, Misook ^{[5
]}

Pandey, Sadanand ^{[5
]}

机构：

[1] Quaid I Azam Univ, Dept Pharm, Islamabad 45320, Pakistan

[2] UCL, UCL Canc Inst, London WC1E 6DD, England

[3] King Abdulaziz Univ, Coll Med, Dept Pharmacol, Jeddah 21589, Saudi Arabia

[4] Univ Zabol, Fac Sci, Dept Phys, Zabol 53898615, Iran

[5] Yeungnam Univ, Coll Nat Sci, Dept Chem, 280 Daehak Ro, Gyongsan 38541, Gyeongbuk, South Korea

来源：

NANOMATERIALS | 2021年 / 11卷 / 05期

基金：

新加坡国家研究基金会;

关键词：

biofilms formation; pharmacokinetics; drug delivery; anti-bacterial activity; FORMULATION; BIOFILM;

D O I：

10.3390/nano11051086

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Ciprofloxacin (CIP), a potent anti-bacterial agent of the fluroquinolone family, shows poor solubility and permeability, thus leading to the development of intracellular pathogens induced multi-drug resistance and biofilms formation. To synergistically improve the biopharmaceutical parameters of CIP, a hyaluronic acid (FDA approved biocompatible polymer) functionalized self-nano emulsifying drug delivery system (HA-CIP-SNEDDS) was designed in the present study. SNEDDS formulations were tested via solubility, droplet size, zeta potential, a polydispersity index, thermodynamic stability, surface morphology, solid-state characterization, drug loading/release, cellular uptake, and biocompatibility. The final (HA-CIP-SNEDDS) formulation exhibited a mean droplet size of 50 nm with the 0.3 poly dispersity index and negative zeta potential (-11.4 mV). HA-based SNEDDS containing CIP showed an improved ability to permeate goat intestinal mucus. After 4 h, CIP-SNEDDS showed a 2-fold and HA-CIP-SNEDDS showed a 4-fold permeation enhancement as compared to the free CIP. Moreover, 80% drug release of HA-CIP-SNEDDS was demonstrated to be superior and sustained for 72 h in comparison to free CIP. However, anti-biofilm activity of HA-CIP-SNEDDS against Salmonella typhi was higher than CIP-SNEDDS and free CIP. HA-CIP-SNEDDS exhibited increased biocompatibility and improved oral pharmacokinetics as compared to free CIP. Taken together, HA-CIP-SNEDDS formulation seems to be a promising agent against Salmonella typhi with a strong targeting potential.

引用

页数：19

共 43 条

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