Clinical Correlates of HIV-Associated Neurocognitive Disorders in South Africa

被引:74
作者
Joska, John A. [1 ]
Fincham, Dylan S. [2 ]
Stein, Dan J. [1 ]
Paul, Robert H. [3 ]
Seedat, Soraya [2 ]
机构
[1] Univ Cape Town, Dept Psychiat & Mental Hlth, ZA-7925 Cape Town, South Africa
[2] Univ Stellenbosch, Dept Psychiat, MRC Unit Anxiety & Stress Disorders, ZA-7600 Stellenbosch, South Africa
[3] Univ Missouri, Dept Psychol & Behav Neurosci, St Louis, MO 63121 USA
基金
英国医学研究理事会; 新加坡国家研究基金会;
关键词
HIV-associated neurocognitive disorders; HIV Dementia Scale (HDS); South Africa; Alcohol abuse; Post-traumatic stress disorder; COGNITIVE IMPAIRMENT; DEMENTIA-SCALE; RISK-FACTORS; DISEASE PROGRESSION; ALCOHOL; INFECTION; INDIVIDUALS; DEPRESSION; HIV/AIDS; TRAUMA;
D O I
10.1007/s10461-009-9538-x
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Human immunodeficiency virus-associated neurocognitive disorders (HAND) occurs globally and across different genetic clades of the virus. However, few studies have examined HAND in South Africa, despite the prevalence of HIV in this region of the world, and the predominance of clade C. The present study examined the relationship between a number of demographic and clinical variables in a sample of 536 patients attending HIV clinics in South Africa. HAND was present in 23.5% of the sample and was associated with older age, a low educational level among those with post-traumatic stress disorder (PTSD) and alcohol abuse among those with many months since diagnosis. These results suggest that HAND is common among patients in South Africa, and is associated with clinical variables such as PTSD and alcohol abuse. This underlines the impact of HIV on the nervous system and the importance of screening for co morbid mental health conditions.
引用
收藏
页码:371 / 378
页数:8
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