The effects of allyl chloride on Ca2+, Ca2+-free CaM, cAMP and Ca2+/CaM-PK II activity in nerve cells

被引：0
作者：
Xie, KQ [1 ]
Gao, SJ [1 ]
Zhang, L [1 ]
Zhang, M [1 ]
Sun, KR [1 ]
机构：
[1] Shandong Med Univ, Inst Toxicol, Jinan 250012, Peoples R China
来源：
JOURNAL OF OCCUPATIONAL HEALTH | 1998年 / 40卷 / 01期
关键词：
allyl chloride; nerve cell; Ca2+; CaM; cAMP; Ca2+/CaM-PK II; neurotoxicity;
D O I：
10.1539/joh.40.50
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Nerve cells in a culture from chicken embryo brain were used to study the allyl chloride-induced effects on the contents of intracellular Ca2+, Ca2+-free CaM, cAMP and the activity of Ca2+/CaM-PK II. The results showed that with the increase in the concentration of allyl chloride there was a significant increase in the content of Ca2+ and cAMP, and the activity of Ca2+/CaM-PK II in the cells (P<0.01), but a marked decrease in Ca2+-free CaM (P<0.01). The results suggest that the neurotoxicity of allyl chloride might be related to the increase in intracellular Ca2+ and the activation of CaM and Ca2+/CaM-PK II, eventually leading to the accumulation of degenerative MT in the nerve axon.
引用
收藏
页码：50 / 54
页数：5
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