Bonelike apatite formation on ethylene-vinyl alcohol copolymer modified with silane coupling agent and calcium silicate solutions

被引：103

作者：

Oyane, A

Kawashita, M

Nakanishi, K

Kokubo, T

Minoda, M

Miyamoto, T

Nakamura, T

机构：

[1] Kyoto Univ, Grad Sch Engn, Dept Chem Mat, Sakyo Ku, Kyoto 6068501, Japan

[2] Kyoto Inst Technol, Fac Engn & Design, Dept Chem & Mat Technol, Sakyo Ku, Kyoto 6068585, Japan

[3] Matsue Natl Coll Technol, Matsue, Shimane 6908518, Japan

[4] Kyoto Univ, Grad Sch Med, Dept Orthopaed Surg, Sakyo Ku, Kyoto 6068507, Japan

来源：

BIOMATERIALS | 2003年 / 24卷 / 10期

关键词：

ethylene-vinyl alcohol copolymer; silane coupling agent; calcium silicate; apatite; biomimetic process;

D O I：

10.1016/S0142-9612(02)00581-1

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

An ethylene-vinyl alcohol copolymer (EVOH) was treated with a silane coupling agent and calcium silicate solutions, and then soaked in a simulated body fluid (SBF) with ion concentrations approximately equal to those of human blood plasma. A smooth and uniform bonelike apatite layer was successfully formed on both the EVOH plate and the EVOH-knitted fibers in SBF within 2 days. Part of the structure of the resulting apatite-EVOH fiber composite was similar to that of natural bone. If this kind of composite can be fabricated into a three-dimensional structure similar to natural bone, the resultant composite is expected to exhibit both mechanical properties analogous to those of natural bone and bone-bonding ability. Hence, it has great potential as a bone substitute. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：1729 / 1735

页数：7

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