Armadillo/β-catenin signals in the nucleus -: proof beyond a reasonable doubt?

被引：123
作者：
Bienz, M
Clevers, H
机构：
[1] MRC, Mol Biol Lab, Cambridge CB2 2QH, England
[2] Netherlands Inst Dev Biol, NL-3584 CT Utrecht, Netherlands
来源：
NATURE CELL BIOLOGY | 2003年 / 5卷 / 03期
关键词：
D O I：
10.1038/ncb0303-179
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Wnt signalling results in transcriptional stimulation of genes controlling normal and malignant development. A key effector of the canonical Wnt pathway is beta-catenin (also known as Drosophila melanogaster Armadillo (Arm)), thought to function as a nuclear co-activator of TCF transcription factors. This has been challenged by unexpected observations of membrane-bound Arm/beta-catenin signalling activity. Plausible explanations allow these observations to be reconciled with the large body of evidence supporting a nuclear function of Arm/beta-catenin.
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页码：179 / 182
页数：4
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