Immune response of BALB/c mice against an experimental vaccine of Alum precipitated autoclaved Leishmania major (Alum-ALM) mixed with BCG or Mycobacterium vaccae

被引：0
作者：
Nateghi, Rostami M. [2 ,3 ]
Keshavarz, H. [2 ,3 ]
Khamesipour, A. [1 ]
机构：
[1] Univ Tehran Med Sci, Ctr Res & Training Skin Dis & Leprosy, Tehran, Iran
[2] Univ Tehran Med Sci, Med Parasitol & Mycol Dept, Sch Publ Hlth, Tehran, Iran
[3] Univ Tehran Med Sci, Publ Hlth Res Inst, Tehran, Iran
来源：
TROPICAL BIOMEDICINE | 2010年 / 27卷 / 01期
关键词：
AMERICAN CUTANEOUS LEISHMANIASIS; PLACEBO-CONTROLLED TRIAL; VISCERAL LEISHMANIASIS; DOUBLE-BLIND; PLUS BCG; QUANTIFYING LEISHMANIA; PROTECTIVE IMMUNITY; CANDIDATE VACCINE; TREATMENT FAILURE; INTERFERON-GAMMA;
D O I：
暂无
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Immune response in BALB/c mice immunized 3 times with different doses (50 jig or 200 mu g of protein) of Alum precipitated autoclaved Leishmania major (Alum-ALM) mixed with either BCG (1 x 10(7) CFU) or different doses of killed Mycobacterium vaccae (1 x 10(6), 1 x 10(7)) was assessed. Mice immunized with low dose of Alum-ALM mixed with either BCG or low M. vaccae showed a significantly higher IFN-gamma, production and a lower IL-4 level and a significantly lower parasite burden compared to the control PBS injected group. It seems that immunization with a low dose of Alum-ALM mixed with an adjuvant induces a Th1 type of immune response in susceptible BALB/c mice.
引用
收藏
页码：89 / 102
页数：14
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