Highly enantioselective Michael-cyclization cascade promoted by synergistic asymmetric aminocatalysis and Lewis acid catalysis

被引：34

作者：

Yu, Chenguang ^{[1
,2
]}

Zhang, Yinan ^{[2
]}

Zhang, Shilei ^{[2
]}

He, Jing ^{[1
]}

Wang, Wei ^{[2
]}

机构：

[1] Beijing Inst Chem Technol, State Key Lab Chem Resources Engn, Beijing 100029, Peoples R China

[2] Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 13期

关键词：

Cascade; Michael; Organocatalysis; Pd catalysis; TRANSITION-METAL CATALYSIS; DIPHENYLPROLINOL SILYL ETHER; ALPHA; BETA-UNSATURATED ALDEHYDES; ALDOL REACTIONS; BRONSTED ACID; ADDITION-REACTIONS; DOMINO REACTIONS; STEREOCENTERS; ALDER REACTIONS; GOLD CATALYSIS;

D O I：

10.1016/j.tetlet.2010.01.096

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The novel dual cooperative asymmetric aminocatalysis and Lewis acid catalysis has been successfully developed for promoting cascade Michael-cyclization reaction with high enantio-, regio- and chemo-selectivity. The simple and practical process affords a one-pot approach to synthetically useful cyclopentenes. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：1742 / 1744

页数：3

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