Telomerase - Going beyond the ends

被引：9

作者：

De Semir, David

Nosrati, Mehdi

Li, Shang

Kashani-Sabet, Mohammed

机构：

[1] Univ Calif San Francisco, Ctr Comprehens Canc, Auerback Melanoma Res Lab, Cutaneous Oncol Program,Dept Dermatol, San Francisco, CA 94115 USA

[2] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA

来源：

CELL CYCLE | 2007年 / 6卷 / 05期

关键词：

melanoma; metastasis; glycolysis; gene therapy; ribozyme; gene expression profiling;

D O I：

10.4161/cc.6.5.3980

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

To date, the major function attributed to telomerase has been the elongation of telomeres. Recent studies have assigned new biochemical properties to telomerase by implicating a role in tumor metastasis and cellular differentiation by virtue of its modulation of novel cell signaling pathways such as glycolysis. In this Perspective we will discuss these recent results that have provided additional insight into the involvement of telomerase in cellular processes other than telomere maintenance at chromosome ends.

引用

页码：546 / 549

页数：4

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