High-Content Screening: A Decade of Evolution

被引：33

作者：

Thomas, Nick ^{[1
]}

机构：

[1] GE Healthcare, Maynard Ctr, Forest Farm Whitchurch, Cardiff CF14 7YT, S Glam, Wales

来源：

JOURNAL OF BIOMOLECULAR SCREENING | 2010年 / 15卷 / 01期

关键词：

high-content screening; imaging; image analysis; phenotypic screening; platform evolution; GROWTH-FACTOR RECEPTOR; IN-VITRO; KINASE INHIBITORS; DRUG DISCOVERY; PROTEIN; IDENTIFICATION; ACTIVATION; MICROSCOPY; CELLS; THERAPEUTICS;

D O I：

10.1177/1087057109353790

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

In the past decade, high-content screening has become a highly developed approach to obtaining richly descriptive quantitative phenotypic data using automated microscopy. From early use in drug screening, the technique has evolved to embrace a diverse range of applications in both academic and industrial sectors and is now widely recognized as providing an efficient and effective approach to large-scale programs investigating cell biology in situ and in context. (Journal of Biomolecular Screening 2010: 1-9)

引用

页码：1 / 9

页数：9

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