Bizarre and scary ECG in yew leaves poisoning: Report of successful treatment

被引:3
作者
Cerrato, Natascia [1 ]
Calzolari, Gilberto [2 ]
Tizzani, Pietro [2 ]
Perinetto, Emma Actis [1 ]
Dellavalle, Antonio [1 ]
Aluffi, Enzo [2 ]
机构
[1] Osped San Lazzaro, Div Cardiol, Alba, CN, Italy
[2] Osped San Lazzaro, Emergency Dept, Alba, CN, Italy
关键词
poisoning; taxine; ventricular arrhythmias; yew leaves; INTOXICATION; INGESTION; ALKALOIDS; TOXICITY;
D O I
10.1111/anec.12535
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Yew leaves poisoning is a rare life-threatening intoxication, whose diagnosis can be difficult. Initial symptoms are nausea, vomiting, abdominal pain, dizziness, tachycardia, muscle weakness, confusion, beginning within 1hr from ingestion and followed by bradycardia, ventricular arrhythmias, ventricular fibrillation, severe hypotension, and death. Taxine-derived alkaloids are responsible for the toxicity of the yew leaves, blocking sodium and calcium channels, and causing conduction abnormalities. Because of lack of a specific antidote and limited efficacy of common antiarrhythmic drugs, prompt diagnosis, detoxification measures, and immediate hemodynamic support (also with transvenous cardiac stimulation) are essential.
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页数:5
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