Engaging plasticity: Differentiation therapy in solid tumors

被引:22
作者
Bar-Hai, Neta [1 ,2 ]
Ishay-Ronen, Dana [1 ,2 ]
机构
[1] Chaim Sheba Med Ctr, Oncol Inst, Canc Res Ctr, Tel Aviv, Israel
[2] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel
关键词
cancer cell plasticity; EMT; differentiation therapy; trans-differentiation; TGFb signaling; solid tumors; HISTONE DEACETYLASE INHIBITOR; EPITHELIAL-MESENCHYMAL TRANSITION; ACUTE PROMYELOCYTIC LEUKEMIA; BONE-MARROW-TRANSPLANTATION; COLONY-STIMULATING FACTOR; ACTIVATED RECEPTOR-GAMMA; HIGH-RISK NEUROBLASTOMA; NEGATIVE FEEDBACK LOOP; BREAST-CANCER CELLS; RETINOIC ACID;
D O I
10.3389/fphar.2022.944773
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Cancer is a systemic heterogeneous disease that can undergo several rounds of latency and activation. Tumor progression evolves by increasing diversity, adaptation to signals from the microenvironment and escape mechanisms from therapy. These dynamic processes indicate necessity for cell plasticity. Epithelial-mesenchymal transition (EMT) plays a major role in facilitating cell plasticity in solid tumors by inducing dedifferentiation and cell type transitions. These two practices, plasticity and dedifferentiation enhance tumor heterogeneity creating a key challenge in cancer treatment. In this review we will explore cancer cell plasticity and elaborate treatment modalities that aspire to overcome such dynamic processes in solid tumors. We will further discuss the therapeutic potential of utilizing enhanced cell plasticity for differentiation therapy.
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页数:14
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