Metronomic chemotherapy and nanocarrier platforms

被引：17
作者：
Abu Lila, Amr S. [1 ,2 ,3 ]
Ishida, Tatsuhiro [1 ]
机构：
[1] Univ Tokushima, Inst Med Biosci, Dept Pharmacokinet & Biopharmaceut, 1-78-1 Sho Machi, Tokushima 7708505, Japan
[2] Zagazig Univ, Dept Pharmaceut & Ind Pharm, Fac Pharm, Zagazig 44519, Egypt
[3] Hail Univ, Dept Pharmaceut, Fac Pharm, Hail 2440, Saudi Arabia
来源：
CANCER LETTERS | 2017年 / 400卷
关键词：
Dosing schedule; Liposomes; Maximum tolerated dose; Metronomic chemotherapy; Nanoparticles; Tumor priming; ACCELERATED BLOOD CLEARANCE; METASTATIC BREAST-CANCER; PEGYLATED LIPOSOMAL DOXORUBICIN; ADVANCED HEPATOCELLULAR-CARCINOMA; COATED CATIONIC LIPOSOMES; LOW-DOSE CYCLOPHOSPHAMIDE; ENDOTHELIAL GROWTH-FACTOR; RECURRENT OVARIAN-CANCER; COLORECTAL TUMOR-MODEL; STEM-LIKE CELLS;
D O I：
10.1016/j.canlet.2016.11.007
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The therapeutic concept of administering chemotherapeutic agents continuously at lower doses, relative to the maximum tolerated dose (MTD) without drug-free breaks over extended periods -known as "metronomic chemotherapy" - is a promising approach for anti-angiogenic cancer therapy. In comparison with MTD chemotherapy regimens, metronomic chemotherapy has demonstrated reduced toxicity. However, as a monotherapy, metronomic chemotherapy has failed to provide convincing results in clinical trials. Therapeutic approaches including combining the anti-angiogenic "metronomic" therapy with conventional radio-/chemo-therapy and/or targeted delivery of chemotherapeutic agents to tumor tissues via their encapsulation with nanocarrier-based platforms have proven to potentiate the overall therapeutic outcomes. In this review, therefore, we focused on the mutual contribution made by nanoscale drug delivery platforms to the therapeutic efficacy of metronomic-based chemotherapy. In addition, the influence that the dosing schedule has on the overall therapeutic efficacy of metronomic chemotherapy is discussed. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：232 / 242
页数：11
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