Comparing three-year extension of early intervention service to regular care following two years of early intervention service in first-episode psychosis: a randomized single blind clinical trial

被引：58

作者：

Malla, Ashok ^{[1
,2
]}

Joober, Ridha ^{[1
,2
]}

Iyer, Srividya ^{[1
,2
]}

Norman, Ross ^{[3
,4
,5
,6
]}

Schmitz, Norbert ^{[1
,7
]}

Brown, Thomas ^{[1
,7
]}

Lutgens, Danyael ^{[1
,2
]}

Jarvis, Eric ^{[1
,8
]}

Margolese, Howard C. ^{[1
,9
]}

Casacalenda, Nicola ^{[1
,8
]}

Abdel-Baki, Amal ^{[10
]}

Latimer, Eric ^{[1
,7
]}

Mustafa, Sally ^{[2
]}

Abadi, Sherezad ^{[2
]}

机构：

[1] McGill Univ, Dept Psychiat, Montreal, PQ, Canada

[2] Douglas Mental Hlth Univ Inst, Montreal, PQ, Canada

[3] Univ Western Ontario, Dept Psychiat, London, ON, Canada

[4] Univ Western Ontario, Dept Epidemiol, London, ON, Canada

[5] Univ Western Ontario, Dept Biostat, London, ON, Canada

[6] London Hlth Sci Ctr, London, ON, Canada

[7] Douglas Hosp, Montreal, PQ, Canada

[8] Jewish Gen Hosp, Montreal, PQ, Canada

[9] McGill Univ, Hlth Ctr, Montreal, PQ, Canada

[10] Univ Montreal, Hosp Ctr, Montreal, PQ, Canada

来源：

WORLD PSYCHIATRY | 2017年 / 16卷 / 03期

基金：

加拿大健康研究院;

关键词：

First-episode psychosis; extension of early intervention service; regular care; positive symptoms; negative symptoms; outcome; remission; 1ST EPISODE; STANDARD TREATMENT; MULTICENTER TRIAL; NEGATIVE SYMPTOMS; SCHIZOPHRENIA; REMISSION; COGNITION; RECOVERY; PROGRAM;

D O I：

10.1002/wps.20456

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

This study aimed to determine if, following two years of early intervention service for first-episode psychosis, three-year extension of that service was superior to three years of regular care. We conducted a randomized single blind clinical trial using an urn randomization balanced for gender and substance abuse. Participants were recruited from early intervention service clinics in Montreal. Patients (N=220), 18-35 years old, were randomized to an extension of early intervention service (EEIS; N=110) or to regular care (N=110). EEIS included casemanagement, family intervention, cognitive behaviour therapy and crisis intervention, while regular care involved transfer to primary (community health and social services and family physicians) or secondary care (psychiatric outpatient clinics). Cumulative length of positive and negative symptom remission was the primary outcome measure. EEIS patients had a significantly longer mean length of remission of positive symptoms (92.5 vs. 63.6 weeks, t=4.47, p< 0.001), negative symptoms (73.4 vs. 59.6 weeks, t=2.84, p=0.005) and both positive and negative symptoms (66.5 vs. 56.7 weeks, t=2.25, p=0.03) compared to regular care patients. EEIS patients stayed in treatment longer than regular care patients (mean 131.7 vs. 105.3 weeks, t=3.98, p< 0.001 through contact with physicians; 134.8637.7 vs. 89.8+55.2, t=6.45, p< 0.0001 through contact with other health care providers) and received more units of treatment (mean 74.9 vs. 39.9, t=4.21, p< 0.001 from physicians, and 57.3 vs. 28.2, t=4.08, p< 0.001 from other health care professionals). Length of treatment had an independent effect on the length of remission of positive symptoms (t=2.62, p=0.009), while number of units of treatment by any health care provider had an effect on length of remission of negative symptoms (t=22.70, p=0.008) as well as total symptoms (t=22.40, p=0.02). Post-hoc analysis showed that patients randomized to primary care, based on their better clinical profile at randomization, maintained their better outcome, especially as to remission of negative symptoms, at the end of the study. These data suggest that extending early intervention service for three additional years has a positive impact on length of remission of positive and negative symptoms compared to regular care. Thismay have policy implications for extending early intervention services beyond the current two years.

引用

页码：278 / 286

页数：9