Potentially malignant disorders of the oral and oropharyngeal mucosa; present concepts of management

被引：131
作者：
van der Waal, Isaac [1 ]
机构：
[1] Vrije Univ Amsterdam Med Ctr, Acad Ctr Dent Amsterdam ACTA, Dept Oral & Maxillofacial Surg Pathol, NL-1007 MB Amsterdam, Netherlands
来源：
ORAL ONCOLOGY | 2010年 / 46卷 / 06期
关键词：
Oral leukoplakia; Oral lichen planus; Potentially malignant oral disorders; PROLIFERATIVE VERRUCOUS LEUKOPLAKIA; SQUAMOUS-CELL CARCINOMA; LICHEN-PLANUS; PREMALIGNANT LESIONS; RISK; CLASSIFICATION; PREVALENCE; CRITERIA;
D O I：
10.1016/j.oraloncology.2010.02.016
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In spite of tremendous progress in the. field of molecular biology there is yet no single marker that reliably predicts malignant transformation of a potentially malignant disorder of the oral mucosa. Therefore, it is recommended to excise or laser any oral of oropharyngeal leukoplakia/erythroplakia, if feasible, irrespective of the presence or absence of dysplasia. However, it is actually unknown whether such removal truly prevents the possible development of a squamous cell carcinoma. Therefore, lifelong follow-up is recommended at intervals of no more than 6 months. At present, oral lichen planus is more or less accepted as being a potentially malignant disorder. There are no means to prevent such event. The efficacy of follow-up of oral lichen planus is questionable. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：423 / 425
页数：3
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