The Association between Pediatric NAFLD and Common Genetic Variants

被引：9

作者：

Umano, Giuseppina Rosaria ^{[1
,2
]}

Martino, Mariangela ^{[1
,3
]}

Santoro, Nicola ^{[1
,3
]}

机构：

[1] Yale Univ, Dept Pediat, New Haven, CT 06520 USA

[2] Univ Campania Luigi Vanvitelli, Dipartimento Donna Bambino Vhirurgia Gen & Specia, I-80138 Naples, Italy

[3] Univ Molise, Dipartimento Med Tiberio V, I-86100 Campobasso, Italy

来源：

CHILDREN-BASEL | 2017年 / 4卷 / 06期

关键词：

NAFLD; children; genetics; FATTY LIVER-DISEASE; TRIGLYCERIDE TRANSFER PROTEIN; GENOME-WIDE ASSOCIATION; N-METHYLTRANSFERASE GENE; NECROSIS-FACTOR-ALPHA; LEPTIN RECEPTOR GENE; PLASMA ALT LEVELS; NONALCOHOLIC FATTY; INSULIN-RESISTANCE; METABOLIC SYNDROME;

D O I：

10.3390/children4060049

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Non-alcoholic fatty liver disease (NAFLD) is one of the most common complications of obesity. Several studies have shown that genetic predisposition probably plays an important role in its pathogenesis. In fact, in the last few years a large number of genetic studies have provided compelling evidence that some gene variants, especially those in genes encoding proteins regulating lipid metabolism, are associated with intra-hepatic fat accumulation. Here we provide a comprehensive review of the gene variants that have affected the natural history of the disease.

引用

页数：14

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