Sensitization of Radiation or Gemcitabine-Based Chemoradiation Therapeutic Effect by Nimotuzumab in Pancreatic Cancer Cells

被引：9
作者：
Gao, Chunzi [1 ]
Wu, Xianzhen [1 ,2 ]
Yan, Ying [1 ,3 ]
Meng, Lingnan [1 ]
Shan, Dan [1 ]
Li, Ying [1 ]
Han, Bo [1 ]
机构：
[1] Harbin Med Univ, Affiliated Hosp 1, Dept Oncol, Ward 2, Harbin, Peoples R China
[2] Tumor Hosp Shanxi Prov, Comprehens Special Needs Dept, Taiyuan, Peoples R China
[3] First Hosp Harbin City, Dept Oncol, Harbin, Peoples R China
来源：
TECHNOLOGY IN CANCER RESEARCH & TREATMENT | 2016年 / 15卷 / 03期
关键词：
nimotuzumab; epidermal growth factor receptor; radiation; chemoradiation; gemcitabine; cell cycle; apoptosis; GROWTH-FACTOR-RECEPTOR; CARCINOMA-CELLS; EGFR; ANTIBODY; RADIOTHERAPY; DOCETAXEL; SURVIVAL; ZD1839; LINES; HEAD;
D O I：
10.1177/1533034615585209
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
This study was performed to observe the effect of the combination of nimotuzumab with radiation or gemcitabine-based chemoradiation on antipancreatic cancer cell therapy. Pancreatic cancer cells (PANC-1) were treated with nimotuzumab alone or combined with radiation (2, 4, or 8 Gy), which was either with or without gemcitabine chemotherapy. Cell proliferation, cell cycle distribution, and apoptosis were observed. The inhibition rate, the percentage of G2/M phase arrest, and the apoptosis rate of the combined nimotuzumab with radiation group was significantly higher than the group without nimotuzumab (P <.001). The inhibition rate, the percentage of G2/M phase, and the apoptosis rate of the nimotuzumab therapy combined with gemcitabine-based chemoradiation group were obviously higher than that in gemcitabine-based chemoradiation group (P <.001). In conclusion, nimotuzumab could enhance the anticancer effect of radiation and gemcitabine-based chemoradiation in PANC-1 cancer cells because of the enhancement of cell cycle arrest and apoptosis.
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收藏
页码：446 / 452
页数：7
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