New Cytochalasin Derivatives from Deep-Sea Cold Seep-Derived Endozoic Fungus Curvularia verruculosa CS-129

被引：7

作者：

Hu, Xue-Yi ^{[1
,2
,3
]}

Li, Xiao-Ming ^{[1
,2
]}

Yang, Sui-Qun ^{[1
,2
]}

Wang, Bin-Gui ^{[1
,2
,3
,4
]}

Meng, Ling-Hong ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China

[2] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China

[3] Univ Chinese Acad Sci, Coll Marine Sci, Yuquan Rd 19 A, Beijing 100049, Peoples R China

[4] Chinese Acad Sci, Ctr Ocean Megasci, Nanhai Rd 7, Qingdao 266071, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2022年 / 19卷 / 08期

基金：

中国国家自然科学基金;

关键词：

endozoic fungus; Curvularia verruculosa; marine natural products; cytochalasin derivatives; antimicrobial activity;

D O I：

10.1002/cbdv.202200550

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two new antimicrobial cytochalasin derivatives, 6 beta,7 beta-epoxydeoxaphomin C (1) and 12-hydroxydeoxaphomin C (2), a new natural occurring product 24-nor-cytochalasin B (3), together with two related known analogs (4-5) were isolated and identified from an endozoic fungus Curvularia verruculosa CS-129, isolated from the deep-sea squat lobster Shinkaia crosnieri which was collected in cold seep region of south China sea. The structures of new compounds were elucidated on the basis of detailed spectroscopic analysis and ECD calculation. The spectroscopic data of 24-nor-cytochalasin B (3) were reported for the first time. All compounds were tested for their antibacterial activities against human and aquatic pathogenic bacteria.

引用

页数：7

共 21 条

[1] PROXIPHOMIN AND PROTOPHOMIN, 2 NEW CYTOCHALASANES [J].