Subclinical organ damage and cardiovascular risk prediction

被引：10

作者：

Sehestedt, Thomas ^{[1
]}

Olsen, Michael H. ^{[1
]}

机构：

[1] Glostrup Cty Hosp, Cardiovasc Res Unit, Copenhagen, Denmark

来源：

BLOOD PRESSURE | 2010年 / 19卷 / 03期

关键词：

Cardiovascular risk; hypertension; risk stratification; subclinical organ damage; LEFT-VENTRICULAR HYPERTROPHY; INTIMA-MEDIA THICKNESS; END-POINT REDUCTION; CHRONIC KIDNEY-DISEASE; LOSARTAN INTERVENTION; HYPERTENSIVE PATIENTS; CORONARY CALCIUM; ANTIHYPERTENSIVE TREATMENT; CREATININE CLEARANCE; COMPUTED-TOMOGRAPHY;

D O I：

10.3109/08037051.2010.483054

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Traditional cardiovascular risk factors have poor prognostic value for individuals and screening for subclinical organ damage has been recommended in hypertension in recent guidelines. The aim of this review was to investigate the clinical impact of the additive prognostic information provided by measuring subclinical organ damage. We have (i) reviewed recent studies linking markers of subclinical organ damage in the heart, blood vessels and kidney to cardiovascular risk; (ii) discussed the evidence for improvement in cardiovascular risk prediction using markers of subclinical organ damage; (iii) investigated which and how many markers to measure and (iv) finally discussed whether measuring subclinical organ damage provided benefits beyond risk prediction. In conclusion, more studies and if possible randomized studies are needed to investigate ( i) the importance of markers of subclinical organ damage for risk discrimination, calibration and reclassifi cation; and ( ii) the economic costs and health benefits associated with measuring markers of subclinical organ damage.

引用

页码：132 / 139

页数：8

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