Agitation in patients with dementia: a systematic review of epidemiology and association with severity and course

被引：26

作者：

Anatchkova, Milena ^{[1
]}

Brooks, Anne ^{[1
]}

Swett, Laura ^{[1
]}

Hartry, Ann ^{[2
]}

Duffy, Ruth A. ^{[3
]}

Baker, Ross A. ^{[3
]}

Hammer-Helmich, Lene ^{[4
]}

Aigbogun, Myrlene Sanon ^{[5
]}

机构：

[1] Evidera, Patient Ctr Res, Bethesda, MD USA

[2] Lundbeck LLC, Hlth Econ & Outcomes Res, Deerfield, IL USA

[3] Otsuka Pharmaceut Dev & Commercializat Inc, Med Affairs, Princeton, NJ USA

[4] H Lundbeck & Co AS, Real World Evidence & Epidemiol, Valby, Denmark

[5] Otsuka Pharmaceut Dev & Commercializat Inc, Hlth Econ & Outcomes Res, 508 Carnegie Ctr, Princeton, NJ 08540 USA

来源：

INTERNATIONAL PSYCHOGERIATRICS | 2019年 / 31卷 / 09期

关键词：

agitation; Alzheimer's disease; systematic review; agitation burden; QUALITY-OF-LIFE; NURSING-HOME RESIDENTS; NEUROPSYCHIATRIC SYMPTOMS; ALZHEIMERS-DISEASE; PSYCHOLOGICAL SYMPTOMS; FOLLOW-UP; BEHAVIORAL SYMPTOMS; PEOPLE; PREVALENCE; RISK;

D O I：

10.1017/S1041610218001898

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Objectives: More than 90% of individuals with Alzheimer's disease (AD) experience behavioral and neuropsychiatric symptoms (NPS), such as agitation. However, little is known regarding the specific burden of agitation for Alzheimer's patients. Design: A global systematic literature review was conducted in MEDLINE and Embase for studies of clinical, humanistic, and economic burden of agitation in AD/dementia published from 2006-2016. References of identified papers and related literature reviews were examined. Studies meeting predetermined inclusion criteria for burden of agitation/NPS were summarized. Results: Eighty papers met the inclusion criteria for burden of agitation in dementia. Wide ranges of agitation prevalence were reported, but few papers provided information on incidence. The association of agitation with AD severity was presented in multiple studies; a few suggested positive association of agitation with mortality. Conclusions: High prevalence of agitation is consistent with earlier reports, but several gaps in understanding of agitation in AD need further exploration.

引用

页码：1305 / 1318

页数：14

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