Induced recruitment of NK cells to lymph nodes provides IFN-γ for TH1 priming

被引：1056
作者：
Martín-Fontecha, A
Thomsen, LL
Brett, S
Gerard, C
Lipp, M
Lanzavecchia, A
Sallusto, F
机构：
[1] Inst Res Biomed, CH-6500 Bellinzona, Switzerland
[2] Glaxo Smith & Kline, Stevenage SG1 2NY, Herts, England
[3] Childrens Hosp, Ina Sue Perlmutter Lab, Boston, MA 02115 USA
[4] Harvard Univ, Sch Med, Boston, MA 02115 USA
[5] Max Delbruck Ctr Mol Med, D-13092 Berlin, Germany
来源：
NATURE IMMUNOLOGY | 2004年 / 5卷 / 12期
关键词：
D O I：
10.1038/ni1138
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Naive T cells are stimulated by antigen-presenting dendritic cells (DCs) in secondary lymphoid organs, but whether other types of cell participate in T cell priming is unclear. Here we show in mice that natural killer (NK) cells, which are normally excluded from lymph nodes, are rapidly recruited in a CCR7-independent, CXCR3-dependent manner to lymph nodes on stimulation by the injection of mature DCs. Recruitment of NK cells is also induced by some, but not all, adjuvants and correlates with the induction of T helper cell type 1 (T(H)1) responses. NK cell depletion and reconstitution experiments show that NK cells provide an early source of interferon-gamma (IFN-gamma) that is necessary for T(H)1 polarization. Taken together, our results identify an induced pathway of NK cell migration in antigen-stimulated lymph nodes and a mechanism by which some adjuvants may facilitate T(H)1 responses.
引用
收藏
页码：1260 / 1265
页数：6
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