G4Hunter web application: a web server for G-quadruplex prediction

被引：129

作者：

Brazda, Vaclav ^{[1
]}

Kolomaznik, Jan ^{[2
]}

Lysek, Jiri ^{[2
]}

Bartas, Martin ^{[1
,3
]}

Fojta, Miroslav ^{[1
]}

St'astny, Jiri ^{[2
,4
]}

Mergny, Jean-Louis ^{[1
,5
]}

机构：

[1] Acad Sci Czech Republ, Inst Biophys, Dept Biophys Chem & Mol Oncol, Brno 61265, Czech Republic

[2] Mendel Univ Brno, Dept Informat, Brno 61300, Czech Republic

[3] Univ Ostrava, Fac Sci, Dept Biol & Ecol, Ostrava 71000, Czech Republic

[4] Brno Univ Technol, Tech 2896-2, Brno 61969, Czech Republic

[5] Univ Bordeaux, IECB, CNRS UMR5320, ARNA Lab,Inserm U1212, Pessac, France

来源：

BIOINFORMATICS | 2019年 / 35卷 / 18期

关键词：

REPLICATION; MOTIFS; RNA; DNA; SEQUENCE; REVEALS;

D O I：

10.1093/bioinformatics/btz087

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Motivation: Expanding research highlights the importance of guanine quadruplex structures. Therefore, easy-accessible tools for quadruplex analyses in DNA and RNA molecules are important for the scientific community. Results: We developed a web version of the G4Hunter application. This new web-based server is a platform-independent and user-friendly application for quadruplex analyses. It allows retrieval of gene/nucleotide sequence entries from NCBI databases and provides complete characterization of localization and quadruplex propensity of quadruplex-forming sequences. The G4Hunter web application includes an interactive graphical data representation with many useful options including visualization, sorting, data storage and export.

引用

页码：3493 / 3495

页数：3

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