Aspirin Resistance in Patients Undergoing Hemodialysis and Effect of Hemodialysis on Aspirin Resistance

被引：8

作者：

Aksu, Hale Unal ^{[1
]}

Oner, Ender ^{[1
]}

Celik, Omer ^{[1
]}

Isiksacan, Nilgun ^{[2
]}

Aksu, Huseyin ^{[1
]}

Uzun, Sami ^{[3
]}

Yavuz, Derya ^{[4
]}

Ozturk, Savas ^{[3
]}

Gul, Mehmet ^{[1
]}

Uslu, Nevzat ^{[1
]}

机构：

[1] Mehmet Akif Ersoy Thorac & Cardiovasc Surg Traini, Dept Cardiol, TR-34325 Istanbul, Turkey

[2] Mehmet Akif Ersoy Thorac & Cardiovasc Surg Traini, Dept Biochem, TR-34325 Istanbul, Turkey

[3] Haseki Training & Res Hosp, Dept Nephrol, Istanbul, Turkey

[4] Taksim Training & Res Hosp, Dept Internal Med, Istanbul, Turkey

来源：

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS | 2015年 / 21卷 / 01期

关键词：

aspirin resistance; hemodialysis; Multiplate test; STAGE RENAL-DISEASE; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; PLATELET ACTIVATION; RISK; CLOPIDOGREL; PREVALENCE; MECHANISM; FAILURE; HISTORY;

D O I：

10.1177/1076029613489597

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The aim of this study was to evaluate the prevalence of aspirin resistance (AR) in patients undergoing hemodialysis (HD) and to assess the effect of HD on the results of the Multiplate test. A total of 54 patients undergoing HD were included in this study. Blood samples were taken just before and after the HD session. To determine AR, we used Multiplate test. Platelet aggregation values of the study population were 363.01 +/- 225.69 aggregation unit (AU) x minutes before and 375.33 +/- 254.05 AU x minutes after the HD (P = .597). There was strong correlation between the values before and after HD (R = .755, P < .0001). The AR status was changed in 9 (16.6%) patients after HD. Agreement of AR status before and after HD was substantial ( coefficient = .667, P < .0001). The prevalence of AR in patients undergoing HD seems higher than in most of the studied populations, and this study has shown that the AR statuses of a significant number of patients undergoing HD change after an HD session.

引用

页码：82 / 86

页数：5

共 24 条

[1] Biphasic effects of hemodialysis on platelet reactivity in patients with end-stage renal disease: A potential contributor to cardiovascular risk [J].

Aggarwal, A ;

Kabbani, SS ;

Rimmer, JM ;

Gennari, FJ ;

Taatjes, DJ ;

Sobel, BE ;

Schneider, DJ .

AMERICAN JOURNAL OF KIDNEY DISEASES, 2002, 40 (02) :315-322

[2] Aspirin and clopidogrel - Efficacy, safety, and the issue of drug resistance [J].

Cattaneo, M .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2004, 24 (11) :1980-1987

[3] Hemodialysis effect on platelet count and function and hemodialysis-associated thrombocytopenia [J].

Daugirdas, John T. ;

Bernardo, Angelito A. .

KIDNEY INTERNATIONAL, 2012, 82 (02) :147-157

[4] Carotid artery intima-media thickness correlates with oxidative stress in chronic haemodialysis patients with accelerated atherosclerosis [J].

Dursun, Belda ;

Dursun, Evrim ;

Suleymanlar, Gultekin ;

Ozben, Beste ;

Capraz, Irfan ;

Apaydin, Ali ;

Ozben, Tomris .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2008, 23 (05) :1697-1703

[5] Residual arachidonic acid-induced platelet activation via an adenosine diphosphate-dependent but cyclooxygenase-1-and cyclooxygenase-2-independent pathway - A 700-patient study of aspirin resistance [J].

Frelinger, Andrew L., III ;

Furman, Mark I. ;

Linden, Matthew D. ;

Li, Youfu ;

Fox, Marsha L. ;

Barnard, Marc R. ;

Michelson, Alan D. .

CIRCULATION, 2006, 113 (25) :2888-2896

[6] Does Hemodialysis Affect Clopidogrel Resistance as Measured by VerifyNow® P2Y12 Test? [J].

Geara, Abdallah S. ;

Ayoub, Isabelle ;

Rached, Jacques Abi ;

Siddique, Muhammad N. ;

Ghimire, Pratima ;

El-Sayegh, Suzanne .

AMERICAN JOURNAL OF CARDIOLOGY, 2011, 107 (07) :1103-1104

[7] Aspirin resistance in hemodialysis patients [J].

Geara, Abdallah Sassine ;

Azzi, Nassif ;

Bassil, Claude ;

El-Sayegh, Suzanne .

INTERNATIONAL UROLOGY AND NEPHROLOGY, 2012, 44 (01) :323-325

[8] Aspirin Resistance: Current Status and Role of Tailored Therapy [J].

Grinstein, Jonathan ;

Cannon, Christopher P. .

CLINICAL CARDIOLOGY, 2012, 35 (11) :673-681

[9] EFFECTS OF ACETYLSALICYCLIC ACID IN STROKE PATIENTS EVIDENCE OF NONRESPONDERS IN A SUBPOPULATION OF TREATED PATIENTS [J].

GROTEMEYER, KH .

THROMBOSIS RESEARCH, 1991, 63 (06) :587-593

[10] A prospective, blinded determination of the natural history of aspirin resistance among stable patients with cardiovascular disease [J].

Gum, PA ;

Kottke-Marchant, K ;

Welsh, PA ;

White, J ;

Topol, EJ .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2003, 41 (06) :961-965

← 1 2 3 →